de Kater A W, Melamed S, Epstein D L
Howe Laboratory of Ophthalmology, Harvard Medical School, Boston, MA.
Arch Ophthalmol. 1989 Apr;107(4):572-6. doi: 10.1001/archopht.1989.01070010586035.
We used cationized ferritin, which binds to negatively charged membrane surfaces, as a tracer to delineate the aqueous humor outflow pathway by perfusing it into the anterior chamber of 14 normal human eyes and five with primary open angle glaucoma. In the normal human eyes, diffuse labeling with cationized ferritin was evident throughout the outflow pathway, while in the glaucomatous eyes distinctly different staining patterns were noted. A decorating pattern similar to that seen in normal eyes was observed, as well as apparent areas of underperfusion, suggestive of possible segmental changes in aqueous outflow. These findings may support the hypothesis that primary open angle glaucoma is a segmental disease of the outflow system due to possible regional increases in resistance to aqueous outflow.
我们使用与带负电荷的膜表面结合的阳离子铁蛋白作为示踪剂，通过将其灌注到14只正常人类眼睛和5只原发性开角型青光眼患者眼睛的前房中来描绘房水流出途径。在正常人类眼睛中，整个流出途径都有明显的阳离子铁蛋白弥漫性标记，而在青光眼患者的眼睛中则观察到明显不同的染色模式。观察到一种与正常眼睛相似的装饰性模式，以及明显的灌注不足区域，提示房水流出可能存在节段性变化。这些发现可能支持这样一种假说，即原发性开角型青光眼是一种由于房水流出阻力可能局部增加而导致的流出系统节段性疾病。
