Department of Paediatrics, Sylvanus Olympio Teaching Hospital of Lomé, Togo.
World Health Organization, Regional Office for Africa, Brazzaville, Congo.
Clin Infect Dis. 2016 May 1;62 Suppl 2:S196-9. doi: 10.1093/cid/civ1182.
Togo introduced monovalent rotavirus vaccine starting 19 June 2014. We compared all-cause acute gastroenteritis (AGE) hospitalizations and rotavirus-associated hospitalizations during the prevaccine period (July 2008-June 2014) to 1 year after vaccine introduction (July 2014-June 2015). The proportion of children with AGE who tested positive for rotavirus declined from 53% (645/1223) in prevaccine years to 36% (68/187) in the postvaccine year (P< .01). The decline only occurred in children <1 year of age who were eligible for vaccination and was greatest during the rotavirus season months, supporting that it was associated with vaccine implementation.
多哥自 2014 年 6 月 19 日起开始使用单价轮状病毒疫苗。我们比较了疫苗引入前（2008 年 7 月至 2014 年 6 月）和引入后 1 年（2014 年 7 月至 2015 年 6 月）所有病因急性胃肠炎（AGE）住院和轮状病毒相关住院的情况。轮状病毒检测呈阳性的 AGE 患儿比例从疫苗引入前的 53%（645/1223）下降至疫苗引入后的 36%（68/187）（P＜0.01）。这一下降仅发生在有资格接种疫苗的＜1 岁儿童中，且在轮状病毒流行月份最大，提示其与疫苗实施相关。
