Department of Ophthalmology, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Huangpu District, Shanghai, 200011, China.
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, China.
BMC Ophthalmol. 2020 Dec 7;20(1):477. doi: 10.1186/s12886-020-01744-y.
To evaluate the choroidal changes in Sturge-Weber syndrome (SWS) secondary glaucoma and non-glaucoma port-wine stain (PWS) patients by enhanced depth imaging optical coherence tomography (EDI-OCT).
SWS and PWS patients who were over 3 years old and treated or screened at our ophthalmology department were included in the study. Baseline demographics, EDI-OCT and fundus photography data were collected from all patients.
Overall, 46 non-glaucoma PWS (NGPWS) patients and 35 SWS secondary glaucoma (SG) patients were included, with mean ages of 16.52 ± 13.63 and 13.94 ± 8.27 years, respectively (p > 0.05). Among these patients 2 exhibited bilateral PWS and unilateral glaucoma. Thus, the two eyes of each patient were divided into NGPWS and SG group, respectively. Twenty-one eyes had choroidal hemangiomas and 7 eyes had excessive thickening of the choroid without choroidal hemangiomas. Choroidal hemangiomas were only observed in ipsilateral eyes of SG patients. The choroidal thicknesses of the ipsilateral and fellow eyes of NGPWS patients were 358.10 ± 117.40 μm (45 eyes) and 288.20 ± 79.04 μm (41 eyes), respectively (p < 0.05). The choroidal thicknesses of the ipsilateral and fellow eyes of SG patients were 511.40 ± 242.10 μm (15 eyes) and 283.90 ± 92.27 μm (29 eyes), respectively (p < 0.05). Significant differences were found between the ipsilateral eyes of SWS and PWS patients (p < 0.05). Six of 13 eyes (46%) with choroidal hemangiomas exhibited post-operative posterior segment complications.
NGPWS and SG patients had a thicker choroid in the ipsilateral eye. The trend was even more pronounced in SG patients. Choroidal hemangiomas were only found in the ipsilateral eyes of SG. In addition, choroidal hemangioma was a risk factor for post-operative posterior segment complications in SWS patients.
通过增强深度成像光学相干断层扫描（EDI-OCT）评估 Sturge-Weber 综合征（SWS）继发青光眼和非青光眼葡萄酒色斑（PWS）患者的脉络膜变化。
纳入在我院眼科接受治疗或筛查的年龄大于 3 岁的 SWS 和 PWS 患者。收集所有患者的基线人口统计学资料、EDI-OCT 和眼底照相数据。
共纳入 46 例非青光眼 PWS（NGPWS）患者和 35 例 SWS 继发青光眼（SG）患者，平均年龄分别为 16.52±13.63 岁和 13.94±8.27 岁（p>0.05）。其中 2 例患者双眼均有 PWS，且单侧青光眼。因此，每位患者的双眼分别分为 NGPWS 和 SG 组。21 只眼有脉络膜血管瘤，7 只眼有脉络膜过度增厚而无脉络膜血管瘤。SG 患者仅在同侧眼观察到脉络膜血管瘤。NGPWS 患者同侧眼和对侧眼的脉络膜厚度分别为 358.10±117.40μm（45 只眼）和 288.20±79.04μm（41 只眼）（p<0.05）。SG 患者同侧眼和对侧眼的脉络膜厚度分别为 511.40±242.10μm（15 只眼）和 283.90±92.27μm（29 只眼）（p<0.05）。SWS 和 PWS 患者同侧眼之间存在显著差异（p<0.05）。13 只眼（46%）的 6 只眼（46%）有脉络膜血管瘤，术后出现后节并发症。
NGPWS 和 SG 患者同侧眼的脉络膜较厚。SG 患者的这种趋势更为明显。SG 患者仅在同侧眼发现脉络膜血管瘤。此外，脉络膜血管瘤是 SWS 患者术后后节并发症的危险因素。
