Batters Christopher, Veigel Claudia
Department of Cellular Physiology, Ludwig-Maximilians-Universität München, Schillerstrasse 44, 80336, Munich, Germany.
Center for Nanosciences (CeNS) München, 80799, Munich, Germany.
Traffic. 2016 Aug;17(8):860-71. doi: 10.1111/tra.12400. Epub 2016 May 3.
Many types of cellular motility are based on the myosin family of motor proteins ranging from muscle contraction to exo- and endocytosis, cytokinesis, cell locomotion or signal transduction in hearing. At the center of this wide range of motile processes lies the adaptation of the myosins for each specific mechanical task and the ability to coordinate the timing of motor protein mobilization and targeting. In recent years, great progress has been made in developing single molecule technology to characterize the diverse mechanical properties of the unconventional myosins. Here, we discuss the basic mechanisms and mechanical adaptations of unconventional myosins, and emerging principles regulating motor mobilization and targeting.
许多类型的细胞运动都基于肌球蛋白家族的运动蛋白，范围从肌肉收缩到胞吐作用和胞吞作用、胞质分裂、细胞移动或听觉中的信号转导。在这一系列广泛的运动过程的核心是肌球蛋白针对每个特定机械任务的适应性，以及协调运动蛋白动员和靶向时机的能力。近年来，在开发单分子技术以表征非常规肌球蛋白的多种机械特性方面取得了巨大进展。在这里，我们讨论非常规肌球蛋白的基本机制和机械适应性，以及调节运动蛋白动员和靶向的新出现的原理。
