Tesfaye Markos, Olsen Mette Frahm, Medhin Girmay, Friis Henrik, Hanlon Charlotte, Holm Lotte
Department of Psychiatry, College of Health Sciences, Jimma University, Jimma, Ethiopia ; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Int J Ment Health Syst. 2016 Apr 9;10:29. doi: 10.1186/s13033-016-0062-x. eCollection 2016.
Quality of life of patients is an important element in the evaluation of outcome of health care, social services and clinical trials. The WHOQOL instruments were originally developed for measurement of quality of life across cultures. However, there were concerns raised about the cross-cultural equivalence of the WHOQOL-HIV when used among people with HIV in Ethiopia. Therefore, this study aimed at adapting the WHOQOL-HIV bref for the Ethiopian setting.
A step-wise adaptation of the WHOQOL-HIV bref for use in Ethiopia was conducted to produce an Ethiopian version-WHOQOL-HIV-BREF-Eth. Semantic and item equivalence was tested on 20 people with HIV. One hundred people with HIV were interviewed to test for measurement equivalence (known group validity and internal consistency) of the WHOQOL-HIV-BREF-Eth. Confirmatory factor analysis was conducted using data from 348 people with HIV who were recruited from HIV clinics.
In the process of adaptation, new items of relevance to the context were added while seven items were deleted because of problems with acceptability and poor psychometric properties. The Cronbach's α for the final tool with twenty-seven items WHOQOL-HIV-BREF-Eth was 0.93. All six domains discriminated well between symptomatic and asymptomatic people with HIV (p < 0.001). Using confirmatory factor analysis, a second order factor structure with six first order indicator factors demonstrated moderate fit to the data ((χ(2) = 627.75; DF = 259; p < 0.001), CFI = 0.82, TLI = 0.77 and RMSEA = 0.064).
The WHOQOL-HIV-BREF-Eth has been shown to be a valid measure of quality of life for use in clinical settings among people with HIV in Ethiopia.
患者的生活质量是评估医疗保健、社会服务和临床试验结果的重要因素。世界卫生组织生活质量量表（WHOQOL）最初是为跨文化测量生活质量而开发的。然而，有人对WHOQOL-HIV在埃塞俄比亚艾滋病毒感染者中使用时的跨文化等效性提出了担忧。因此，本研究旨在使WHOQOL-HIV简表适用于埃塞俄比亚的情况。
对WHOQOL-HIV简表进行逐步调整以用于埃塞俄比亚，从而产生埃塞俄比亚版——WHOQOL-HIV-BREF-Eth。对20名艾滋病毒感染者测试了语义和条目等效性。对100名艾滋病毒感染者进行了访谈，以测试WHOQOL-HIV-BREF-Eth的测量等效性（已知组效度和内部一致性）。使用从艾滋病毒诊所招募的348名艾滋病毒感染者的数据进行了验证性因素分析。
在改编过程中，添加了与该背景相关的新项目，同时删除了7个条目，因为存在可接受性问题和心理测量学特性不佳的情况。最终包含27个条目的WHOQOL-HIV-BREF-Eth工具的Cronbach's α为0.93。所有六个领域在有症状和无症状的艾滋病毒感染者之间都有很好的区分度（p < 0.001）。使用验证性因素分析，具有六个一阶指标因素的二阶因素结构显示出与数据的适度拟合（（χ(2)=627.75；DF = 259；p < 0.001），CFI = 0.82，TLI = 0.77，RMSEA = 0.064）。
WHOQOL-HIV-BREF-Eth已被证明是用于埃塞俄比亚艾滋病毒感染者临床环境中生活质量的有效测量工具。
