Vettuparambil Ajith, Rajan Gautham, Chirukandath Ravindran, Culas Terence B
Government Medical College, Thrissur, Kerala 680596 India.
Indian J Surg Oncol. 2015 Dec;6(4):352-5. doi: 10.1007/s13193-015-0425-9. Epub 2015 Jun 12.
Breast cancer is presently the most common cancer among women in Kerala, in Southern India. The objectives of this study were to analyze the epidemiology and pathological characteristics of female breast carcinoma in Kerala. 266 patients who were diagnosed with operable breast cancer between April 2009 and June 2010 were studied. Various pathological characteristics including stage, grade, axillary lymph nodal status, tumor size, and estrogen and progesterone receptor status were studied. Estrogen and progesterone receptor status were evaluated by immunohistochemistry. Chi-square test and frequency tables were used for statistical analysis. The mean age at presentation was 50 years. 48.9 % of the patients were premenopausal. 53.76 % had grade II tumors. Positive axillary lymph nodes were found in 70.3 % patients, and 68 % presented with stage II disease. 54.13 % were ER positive and 62 % were PR positive. The relatively young age at diagnosis, late presentation of the disease, and lower estrogen and progesterone receptor expression compared to patients from the West point toward the need for better breast cancer awareness and screening programmes in Kerala.
乳腺癌目前是印度南部喀拉拉邦女性中最常见的癌症。本研究的目的是分析喀拉拉邦女性乳腺癌的流行病学和病理特征。对2009年4月至2010年6月期间被诊断为可手术乳腺癌的266例患者进行了研究。研究了包括分期、分级、腋窝淋巴结状态、肿瘤大小以及雌激素和孕激素受体状态等各种病理特征。雌激素和孕激素受体状态通过免疫组织化学进行评估。采用卡方检验和频率表进行统计分析。就诊时的平均年龄为50岁。48.9%的患者处于绝经前。53.76%的患者患有Ⅱ级肿瘤。70.3%的患者腋窝淋巴结阳性，68%的患者表现为Ⅱ期疾病。54.13%的患者雌激素受体阳性，62%的患者孕激素受体阳性。与西方患者相比，诊断时相对年轻的年龄、疾病的晚期表现以及较低的雌激素和孕激素受体表达表明喀拉拉邦需要更好的乳腺癌意识和筛查计划。
