Kim Jae Yeol
Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Tuberc Respir Dis (Seoul). 2016 Apr;79(2):70-3. doi: 10.4046/trd.2016.79.2.70. Epub 2016 Mar 31.
In late March of 2009, an outbreak of influenza in Mexico, was eventually identified as H1N1 influenza A. In June 2009, the World Health Organization raised a pandemic alert to the highest level. More than 214 countries have reported confirmed cases of pandemic H1N1 influenza A. In Korea, the first case of pandemic influenza A/H1N1 infection was reported on May 2, 2009. Between May 2009 and August 2010, 750,000 cases of pandemic influenza A/H1N1 were confirmed by laboratory test. The H1N1-related death toll was estimated to reach 252 individuals. Almost one billion cases of influenza occurs globally every year, resulting in 300,000 to 500,000 deaths. Influenza vaccination induces virus-neutralizing antibodies, mainly against hemagglutinin, which provide protection from invading virus. New quadrivalent inactivated influenza vaccine generates similar immune responses against the three influenza strains contained in two types of trivalent vaccines and superior responses against the additional B strain.
2009年3月下旬，墨西哥爆发的一场流感疫情最终被确认为甲型H1N1流感。2009年6月，世界卫生组织将大流行警戒级别提升至最高级别。超过214个国家报告了甲型H1N1流感大流行的确诊病例。在韩国，2009年5月2日报告了首例甲型H1N1流感感染病例。在2009年5月至2010年8月期间，实验室检测确诊了75万例甲型H1N1流感大流行病例。据估计，与H1N1相关的死亡人数达252人。全球每年发生近10亿例流感病例，导致30万至50万人死亡。流感疫苗接种可诱导病毒中和抗体，主要针对血凝素，从而提供针对入侵病毒的保护。新型四价灭活流感疫苗对两种三价疫苗所含的三种流感毒株产生相似的免疫反应，对额外的B型毒株产生更强的反应。
