利用基因组数据阐明铜绿假单胞菌临床分离株中头孢他啶耐药机制
Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data.
作者信息
Kos Veronica N, McLaughlin Robert E, Gardner Humphrey A
机构信息
Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, Massachusetts, USA
Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
出版信息
Antimicrob Agents Chemother. 2016 May 23;60(6):3856-61. doi: 10.1128/AAC.03113-15. Print 2016 Jun.
Abstract
Ceftazidime is one of the few cephalosporins with activity against Pseudomonas aeruginosa Using whole-genome comparative analysis, we set out to determine the prevalent mechanism(s) of resistance to ceftazidime (CAZ) using a set of 181 clinical isolates. These isolates represented various multilocus sequence types that consisted of both ceftazidime-susceptible and -resistant populations. A presumptive resistance mechanism against ceftazidime was identified in 88% of the nonsusceptible isolates using this approach.
摘要
头孢他啶是少数对铜绿假单胞菌有活性的头孢菌素之一。我们利用全基因组比较分析，通过一组181株临床分离株来确定对头孢他啶（CAZ）耐药的普遍机制。这些分离株代表了多种多位点序列类型，包括头孢他啶敏感和耐药群体。使用这种方法，在88%的非敏感分离株中确定了一种推测的头孢他啶耐药机制。
相似文献
1
Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data.利用基因组数据阐明铜绿假单胞菌临床分离株中头孢他啶耐药机制
Antimicrob Agents Chemother. 2016 May 23;60(6):3856-61. doi: 10.1128/AAC.03113-15. Print 2016 Jun.
2
Model system to evaluate the effect of ampD mutations on AmpC-mediated beta-lactam resistance.评估ampD突变对AmpC介导的β-内酰胺耐药性影响的模型系统。
Antimicrob Agents Chemother. 2006 Jun;50(6):2030-7. doi: 10.1128/AAC.01458-05.
3
Antimicrobial Effects of β-Lactams on Imipenem-Resistant Ceftazidime-Susceptible Pseudomonas aeruginosa.β-内酰胺类药物对耐亚胺培南但对头孢他啶敏感的铜绿假单胞菌的抗菌作用
Antimicrob Agents Chemother. 2017 May 24;61(6). doi: 10.1128/AAC.00054-17. Print 2017 Jun.
4
Activity of Ceftolozane-Tazobactam and Ceftazidime-Avibactam against Beta-Lactam-Resistant Pseudomonas aeruginosa Isolates.头孢他洛滨-他唑巴坦和头孢他啶-阿维巴坦对β-内酰胺类耐药铜绿假单胞菌分离株的活性。
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.01858-17. Print 2017 Dec.
5
Distribution of Pseudomonas-Derived Cephalosporinase and Metallo-β-Lactamases in Carbapenem-Resistant Pseudomonas aeruginosa Isolates from Korea.韩国碳青霉烯耐药铜绿假单胞菌分离株中假单胞菌衍生头孢菌素酶和金属β-内酰胺酶的分布
J Microbiol Biotechnol. 2015 Jul;25(7):1154-62. doi: 10.4014/jmb.1503.03065.
6
Outbreak of PER-1 and diversity of β-lactamases among ceftazidime-resistant Pseudomonas aeruginosa clinical isolates.产 PER-1 型头孢他啶耐药铜绿假单胞菌的爆发及β-内酰胺酶的多样性。
J Med Microbiol. 2014 Mar;63(Pt 3):386-392. doi: 10.1099/jmm.0.069427-0. Epub 2014 Jan 7.
7
Phenotypic and genetic resistance traits of Pseudomonas aeruginosa strains infecting cystic fibrosis patients: A French cohort study.法国队列研究：感染囊性纤维化患者的铜绿假单胞菌菌株的表型和遗传耐药特征。
Int J Antimicrob Agents. 2018 Sep;52(3):358-364. doi: 10.1016/j.ijantimicag.2018.05.008. Epub 2018 Jul 18.
8
Mechanisms of resistance in clinical isolates of Pseudomonas aeruginosa less susceptible to cefepime than to ceftazidime.对头孢吡肟的敏感性比对头孢他啶低的铜绿假单胞菌临床分离株的耐药机制。
Clin Microbiol Infect. 2011 Dec;17(12):1817-22. doi: 10.1111/j.1469-0691.2011.03530.x. Epub 2011 May 23.
9
Molecular characterization of multidrug-resistant (MDR) Pseudomonas aeruginosa isolated in a burn center.烧伤中心分离出的多重耐药铜绿假单胞菌的分子特征
Burns. 2017 Feb;43(1):137-143. doi: 10.1016/j.burns.2016.07.002. Epub 2016 Aug 29.
10
Combination of MexAB-OprM overexpression and mutations in efflux regulators, PBPs and chaperone proteins is responsible for ceftazidime/avibactam resistance in Pseudomonas aeruginosa clinical isolates from US hospitals.美罗培南/阿维巴坦耐药的铜绿假单胞菌临床分离株中 MexAB-OprM 过度表达及外排调节蛋白、青霉素结合蛋白和伴侣蛋白突变的联合作用。
J Antimicrob Chemother. 2019 Sep 1;74(9):2588-2595. doi: 10.1093/jac/dkz243.
引用本文的文献
1
Cefepime-taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018-22.头孢吡肟-他尼硼巴坦对肠杆菌科细菌和铜绿假单胞菌耐药临床分离株的活性：2018-2022年GEARS全球监测计划
J Antimicrob Chemother. 2024 Dec 2;79(12):3116-3131. doi: 10.1093/jac/dkae329.
2
Molecular characterization of clinically isolated with varying resistance to ceftazidime-avibactam and ceftolozane-tazobactam collected as a part of the ATLAS global surveillance program from 2020 to 2021.2020 年至 2021 年期间，作为 ATLAS 全球监测计划的一部分收集了具有不同头孢他啶-阿维巴坦和头孢洛扎-他唑巴坦耐药性的临床分离株，并对其进行了分子特征分析。
Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0067024. doi: 10.1128/aac.00670-24. Epub 2024 Sep 10.
3
In-depth analysis of the treatment effect and synergistic mechanism of TanReQing injection on clinical multi-drug resistant .深入分析痰热清注射液对临床多药耐药的治疗效果及协同作用机制。
Microbiol Spectr. 2024 Apr 2;12(4):e0272623. doi: 10.1128/spectrum.02726-23. Epub 2024 Feb 28.
4
Susceptibility profile and β-lactamase content of global isolates resistant to ceftolozane/tazobactam and/or imipenem/relebactam-SMART 2016-21.2016 - 2021年全球对头孢洛扎/他唑巴坦和/或亚胺培南/瑞来巴坦耐药菌株的药敏谱及β-内酰胺酶含量 - SMART研究
JAC Antimicrob Resist. 2023 Jun 28;5(3):dlad080. doi: 10.1093/jacamr/dlad080. eCollection 2023 Jun.
5
Emergence of ST463 -Positive, Imipenem-Nonsusceptible Pseudomonas aeruginosa Isolates in China.中国出现耐亚胺培南铜绿假单胞菌 ST463 阳性分离株。
Microbiol Spectr. 2023 Aug 17;11(4):e0010523. doi: 10.1128/spectrum.00105-23. Epub 2023 Jun 14.
6
Microbial Spectrum and Antibacterial Susceptibility of Endophthalmitis Cultures in a Tertiary Referral Center in the Midwestern United States: An Analysis From 295 Patients.美国中西部一家三级转诊中心眼内炎培养物的微生物谱及抗菌药敏性：来自295例患者的分析
J Vitreoretin Dis. 2020 Sep 22;5(3):216-220. doi: 10.1177/2474126420936454. eCollection 2021 May-Jun.
7
Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program.头孢吡肟-他唑巴坦与对照药物对 2018 年至 2020 年革兰氏阴性杆菌临床分离株的活性：来自全球抗菌药物耐药性监测计划（GEARS）的结果。
Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0128122. doi: 10.1128/aac.01281-22. Epub 2022 Dec 21.
8
Whole-Genome Sequencing Reveals Diversity of Carbapenem-Resistant Collected through CDC's Emerging Infections Program, United States, 2016-2018.全基因组测序揭示了 2016-2018 年美国疾病预防控制中心新兴传染病项目中收集的耐碳青霉烯肠杆菌科的多样性。
Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0049622. doi: 10.1128/aac.00496-22. Epub 2022 Sep 6.
9
Antimicrobial Susceptibility Profiles To Predict the Presence of Carbapenemase Genes among Carbapenem-Resistant Pseudomonas aeruginosa Isolates.抗微生物药敏谱分析预测耐碳青霉烯铜绿假单胞菌分离株中碳青霉烯酶基因的存在。
J Clin Microbiol. 2021 May 19;59(6). doi: 10.1128/JCM.02874-20.
10
Identifying genetic determinants of complex phenotypes from whole genome sequence data.从全基因组序列数据中识别复杂表型的遗传决定因素。
BMC Genomics. 2019 Jun 10;20(1):470. doi: 10.1186/s12864-019-5820-0.
本文引用的文献
1
High-Resolution Analysis by Whole-Genome Sequencing of an International Lineage (Sequence Type 111) of Pseudomonas aeruginosa Associated with Metallo-Carbapenemases in the United Kingdom.通过全基因组测序对英国一株与金属碳青霉烯酶相关的铜绿假单胞菌国际谱系（序列类型111）进行高分辨率分析。
J Clin Microbiol. 2015 Aug;53(8):2622-31. doi: 10.1128/JCM.00505-15. Epub 2015 Jun 3.
2
Dissemination of VIM-2 producing Pseudomonas aeruginosa ST233 at tertiary care hospitals in Egypt.埃及三级护理医院中 VIM-2 型产生铜绿假单胞菌 ST233 的传播。
BMC Infect Dis. 2015 Mar 12;15:122. doi: 10.1186/s12879-015-0861-8.
3
Modification of the susceptibility of gram-negative rods producing ESβLS to β-lactams by the efflux phenomenon.通过外排现象改变产超广谱β-内酰胺酶革兰阴性杆菌对β-内酰胺类药物的敏感性。
PLoS One. 2015 Mar 20;10(3):e0119997. doi: 10.1371/journal.pone.0119997. eCollection 2015.
4
Pseudomonas aeruginosa Diversification during Infection Development in Cystic Fibrosis Lungs-A Review.铜绿假单胞菌在囊性纤维化肺部感染发展过程中的多样化-综述。
Pathogens. 2014 Aug 18;3(3):680-703. doi: 10.3390/pathogens3030680.
5
The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility.铜绿假单胞菌的耐药基因组与表型易感性的关系
Antimicrob Agents Chemother. 2015 Jan;59(1):427-36. doi: 10.1128/AAC.03954-14. Epub 2014 Nov 3.
6
Mutation-driven β-lactam resistance mechanisms among contemporary ceftazidime-nonsusceptible Pseudomonas aeruginosa isolates from U.S. hospitals.美国医院当代对头孢他啶不敏感的铜绿假单胞菌分离株中由突变驱动的β-内酰胺耐药机制
Antimicrob Agents Chemother. 2014 Nov;58(11):6844-50. doi: 10.1128/AAC.03681-14. Epub 2014 Sep 2.
7
Structural and functional characterization of Pseudomonas aeruginosa global regulator AmpR.铜绿假单胞菌全局调节因子AmpR的结构与功能表征
J Bacteriol. 2014 Nov;196(22):3890-902. doi: 10.1128/JB.01997-14. Epub 2014 Sep 2.
8
Extensively drug-resistant pseudomonas aeruginosa isolates containing blaVIM-2 and elements of Salmonella genomic island 2: a new genetic resistance determinant in Northeast Ohio.含有blaVIM-2和沙门氏菌基因组岛2元件的广泛耐药铜绿假单胞菌分离株：俄亥俄州东北部一种新的遗传耐药决定因素
Antimicrob Agents Chemother. 2014 Oct;58(10):5929-35. doi: 10.1128/AAC.02372-14. Epub 2014 Jul 28.
9
The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa.肽聚糖回收在革兰氏阴性肠杆菌科和铜绿假单胞菌β-内酰胺耐药中的哨兵作用。
Bioorg Chem. 2014 Oct;56:41-8. doi: 10.1016/j.bioorg.2014.05.011. Epub 2014 Jun 4.
10
Development of new drugs for an old target: the penicillin binding proteins.开发针对老靶点的新药：青霉素结合蛋白。
Molecules. 2012 Oct 24;17(11):12478-505. doi: 10.3390/molecules171112478.
Zotero 插件