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High-Resolution Analysis by Whole-Genome Sequencing of an International Lineage (Sequence Type 111) of Pseudomonas aeruginosa Associated with Metallo-Carbapenemases in the United Kingdom.通过全基因组测序对英国一株与金属碳青霉烯酶相关的铜绿假单胞菌国际谱系（序列类型111）进行高分辨率分析。
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Pseudomonas aeruginosa Diversification during Infection Development in Cystic Fibrosis Lungs-A Review.铜绿假单胞菌在囊性纤维化肺部感染发展过程中的多样化-综述。
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利用基因组数据阐明铜绿假单胞菌临床分离株中头孢他啶耐药机制

Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data.

作者信息

Kos Veronica N, McLaughlin Robert E, Gardner Humphrey A

机构信息

Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, Massachusetts, USA

Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.

出版信息

Antimicrob Agents Chemother. 2016 May 23;60(6):3856-61. doi: 10.1128/AAC.03113-15. Print 2016 Jun.

DOI:10.1128/AAC.03113-15
PMID:27067331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4879354/
Abstract

Ceftazidime is one of the few cephalosporins with activity against Pseudomonas aeruginosa Using whole-genome comparative analysis, we set out to determine the prevalent mechanism(s) of resistance to ceftazidime (CAZ) using a set of 181 clinical isolates. These isolates represented various multilocus sequence types that consisted of both ceftazidime-susceptible and -resistant populations. A presumptive resistance mechanism against ceftazidime was identified in 88% of the nonsusceptible isolates using this approach.

摘要

头孢他啶是少数对铜绿假单胞菌有活性的头孢菌素之一。我们利用全基因组比较分析，通过一组181株临床分离株来确定对头孢他啶（CAZ）耐药的普遍机制。这些分离株代表了多种多位点序列类型，包括头孢他啶敏感和耐药群体。使用这种方法，在88%的非敏感分离株中确定了一种推测的头孢他啶耐药机制。