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一名52岁白人女性的滤泡性淋巴瘤白血病转化为急性组织细胞白血病

Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman.

作者信息

Steussy Bryan, Lekostaj Jacqueline, Qian Qining, Rosenthal Nancy, Holman Carol J, Syrbu Sergei, Darbro Benjamin, Bossler Aaron, Karandikar Nitin J

机构信息

Department of Pathology, University of Iowa, Iowa City.

Department of Pathology, University of Iowa, Iowa City

出版信息

Lab Med. 2016 May;47(2):155-7. doi: 10.1093/labmed/lmw011.

DOI:10.1093/labmed/lmw011
PMID:27069033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7243928/
Abstract

We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M(5)c)-like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.

摘要

我们报告了一例具有组织细胞分化的急性髓系白血病（急性组织细胞白血病）的典型病例，患者为一名52岁有滤泡性淋巴瘤病史的女性。遗传学研究结果证实了淋巴瘤与白血病细胞之间存在克隆关系。据我们所知，这是滤泡性淋巴瘤向修饰碱基5-甲基胞嘧啶（M(5)c）样急性组织细胞白血病白血病转分化的首例报告，也是首例报道的转分化肿瘤的核型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8326/7243928/eaa3ce46709c/lmw011f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8326/7243928/eaa3ce46709c/lmw011f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8326/7243928/eaa3ce46709c/lmw011f1p.jpg

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