基于临床和实验室数据将血培养分离物分类为污染物和病原体
Classification of Blood Culture Isolates Into Contaminants and Pathogens on the Basis of Clinical and Laboratory Data.
作者信息
Hossain Belal, Weber Martin W, Hamer Davidson H, Hibberd Patricia L, Ahmed A S M Nawshad Uddin, Marzan Mahfuza, Islam Maksuda, Connor Nicholas E, Islam Mohammad Shahidul, Zaidi Anita K, Baqui Abdullah H, Bhutta Zulfiqar A, Qureshi Shahida M, Rafiqullah Iftekhar, McGee Lesley, Saha Samir K
机构信息
From the *Child Health Research Foundation, Dhaka, Bangladesh; †Child and Adolescent Health Department, World Health Organization, Geneva, Switzerland; ‡Department of Global Health and Center for Global Health and Development, Boston University School of Public Health, Boston, Massachusetts; §Division of Global Health, Massachusetts General Hospital, Boston, Massachusetts; ¶Centre for Child and Adolescent Health, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh; ‖Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan; **Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; and ††Streptococcus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia.
出版信息
Pediatr Infect Dis J. 2016 May;35(5 Suppl 1):S52-4. doi: 10.1097/INF.0000000000001107.
The multisite community-based study, Aetiology of Neonatal Infection in South Asia (ANISA), uses blood culture as the gold standard for identifying the etiology of neonatal infection. Considering the importance of this age-old diagnostic tool and the risk of contamination, ANISA has employed rigorous measures to prevent contamination at all stages of blood collection, processing and culture. Because contamination may still occur, an independent expert group evaluates the routinely collected clinical and laboratory data to determine whether a blood culture isolate is a contaminant or a true pathogen. This article describes the methodology used by ANISA to determine whether a blood culture isolate is likely to be a true pathogen or a contaminant in neonatal sepsis.
基于社区的多中心研究“南亚新生儿感染病因学研究（ANISA）”将血培养作为确定新生儿感染病因的金标准。鉴于这种古老诊断工具的重要性以及污染风险，ANISA已采取严格措施，在血液采集、处理和培养的各个阶段防止污染。由于仍可能发生污染，一个独立专家小组会评估常规收集的临床和实验室数据，以确定血培养分离株是污染物还是真正的病原体。本文描述了ANISA用于确定新生儿败血症血培养分离株可能是真正病原体还是污染物的方法。
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