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The formal total synthesis of pentacyclic core alkaloid, (±)-cephalotaxine is achieved in nine steps from known 2-allylpyrrolidine-2-carboxaldehyde using aryne insertion reaction as a key step in 10% overall yield. The developed novel strategy enabled easy access to cephalotaxine congeners.

（±）- 石蒜科碱的五环核心生物碱的全合成是以已知的 2-烯丙基吡咯烷-2-甲醛为原料，经 9 步反应，以芳炔插入反应为关键步骤，总收率为 10%，实现了（±）- 石蒜科碱的全合成。所开发的新策略使石蒜科碱的类似物易于获得。