神经内分泌肿瘤患者治疗前中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值的预后价值：伊兹密尔肿瘤学组研究
Prognostic Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Patients with Neuroendocrine Tumors: An Izmir Oncology Group Study.
作者信息
Salman Tarik, Kazaz Seher Nazli, Varol Umut, Oflazoglu Utku, Unek Ilkay Tugba, Kucukzeybek Yuksel, Alacacioglu Ahmet, Atag Elif, Semiz Huseyin Salih, Cengiz Hakan, Oztop Ilhan, Tarhan Mustafa Oktay
出版信息
Chemotherapy. 2016;61(6):281-6. doi: 10.1159/000445045. Epub 2016 Apr 13.
BACKGROUND
Several studies evaluating the prognostic factors of gastrointestinal and pancreatic neuroendocrine tumors (GEP-NETs) have been published. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have been accepted as prognostic factors for cancer patients.
MATERIALS AND METHODS
This study included 132 patients diagnosed with GEP-NETs. Peripheral blood samples were collected before the pretreatment period.
RESULTS
NLR and PLR were increased as the grade increased in NETs. The embryonic origin analysis revealed higher NLR and PLR rates in NETs of foregut origin. NLR and PLR were also higher in pancreatic NET patients compared to the gastroenteric NET patients. Analysis of NETs by TNM indicated that an advanced stage was accompanied by significantly higher NLR and PLR. We found a strong negative correlation between progression-free survival and NLR and PLR.
CONCLUSION
The study verified that NLR and PLR are simple laboratory findings that can be used to identify NETs with a worse outcome.
背景
已有多项评估胃肠胰神经内分泌肿瘤（GEP-NETs）预后因素的研究发表。中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）已被公认为癌症患者的预后因素。
材料与方法
本研究纳入了132例诊断为GEP-NETs的患者。在预处理期之前采集外周血样本。
结果
在神经内分泌肿瘤中，NLR和PLR随分级增加而升高。胚胎起源分析显示，前肠起源的神经内分泌肿瘤中NLR和PLR率更高。与胃肠神经内分泌肿瘤患者相比，胰腺神经内分泌肿瘤患者的NLR和PLR也更高。根据TNM对神经内分泌肿瘤进行分析表明，晚期患者的NLR和PLR显著更高。我们发现无进展生存期与NLR和PLR之间存在强烈的负相关。
结论
该研究证实，NLR和PLR是简单的实验室指标，可用于识别预后较差的神经内分泌肿瘤。
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