RNA-配体相互作用。(I) 酵母苯丙氨酸转运RNA中的镁结合位点。
RNA-ligant interactions. (I) Magnesium binding sites in yeast tRNAPhe.
作者信息
Holbrook S R, Sussman J L, Warrant R W, Church G M, Kim S H
出版信息
Nucleic Acids Res. 1977 Aug;4(8):2811-20. doi: 10.1093/nar/4.8.2811.
Abstract
X-ray crystallagraphic studies studies indicate that there are at least four site-specifically bound hydrated Mg2+ ions, [Mg(H2O)n]2+, in yeast tRNAPhe. The size and the octahedral coordination geometry, rather than the charge, of [Mg(H2O)N]2+ appear to be the primary reasons for the specificity of magnesium ions in site-binding and in the stabilization of the tertiary structure of tRNA.
摘要
X射线晶体学研究表明，在酵母苯丙氨酸转运核糖核酸（tRNAPhe）中至少有四个位点特异性结合的水合镁离子[Mg(H2O)n]2+。[Mg(H2O)N]2+的大小和八面体配位几何结构，而非电荷，似乎是镁离子在位点结合和tRNA三级结构稳定中具有特异性的主要原因。
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