支气管肺泡灌洗液和血清肿瘤标志物对肺癌的诊断价值
Diagnostic value of bronchoalveolar lavage fluid and serum tumor markers for lung cancer.
作者信息
Wang Hongmin, Zhang Xiaohong, Liu Xinkui, Liu Kangdong, Li Yuexia, Xu Haijiang
机构信息
Department of Respiratory, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
出版信息
J Cancer Res Ther. 2016 Jan-Mar;12(1):355-8. doi: 10.4103/0973-1482.162111.
OBJECTIVE
To analyze the changes of bronchoalveolar lavage fluid (BALF) and serum tumor markers in lung cancer.
MATERIALS AND METHODS
Fifty patients with lung cancer (study group) and 50 cases with benign lung lesions (control group) were selected from May, 2010 to May, 2013. The observation group included squamous cell carcinoma subgroup (n = 25), adenocarcinoma subgroup (n = 19), and small cell undifferentiated carcinoma subgroup (n = 6). The carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and cytokeratin 19 fragment (CYFRA21-1) concentration were compared; and the comparisons among subgroups were also performed.
RESULTS
Three kinds of tumor markers in BALF and serum of the observation group were higher than that of the control group. NSE concentration of small.cell lung cancer was the highest, CYFRA21.1 concentration was highest in the squamous cell carcinoma, and CEA concentration was highest in the adenocarcinoma group; the former increased more significantly.
CONCLUSION
BALF and serum NSE, CEA, and CYFRA21.1 elevated in lung cancer, which had prompt value for pathology, especially significant for BALF.
目的
分析肺癌患者支气管肺泡灌洗液（BALF）及血清肿瘤标志物的变化。
材料与方法
选取2010年5月至2013年5月期间的50例肺癌患者（研究组）和50例肺部良性病变患者（对照组）。观察组包括鳞状细胞癌亚组（n = 25）、腺癌亚组（n = 19）和小细胞未分化癌亚组（n = 6）。比较癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）和细胞角蛋白19片段（CYFRA21-1）的浓度；并对亚组之间进行比较。
结果
观察组BALF及血清中的三种肿瘤标志物均高于对照组。小细胞肺癌的NSE浓度最高，鳞状细胞癌中CYFRA21.1浓度最高，腺癌组中CEA浓度最高；前者升高更显著。
结论
肺癌患者BALF及血清中NSE、CEA和CYFRA21.1升高，对病理诊断有提示价值，对BALF尤为显著。
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