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支气管肺泡灌洗癌胚抗原在肺癌诊断中的效能

Diagnostic efficacy of broncho-alveolar lavage carcino-embronic antigen in carcinoma of lung.

作者信息

Pothal Sudarsan, Patil Kamlesh P, Manjhi Rekha, Dutta Pravati

机构信息

Department of Pulmonary Medicine, V.S.S. Institute of Medical Sciences & Research, Burla, Odisha, India.

Consultant and Intensivist, District General Hospital, Amravati, Maharashtra, India.

出版信息

J Family Med Prim Care. 2019 May;8(5):1725-1729. doi: 10.4103/jfmpc.jfmpc_119_19.

DOI:10.4103/jfmpc.jfmpc_119_19
PMID:31198744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6559055/
Abstract

CONTEXT

Biomarkers can be used for screening lung cancer and the clinician can decide for further invasive workup for diagnosis.

AIMS

To know the diagnostic sensitivity and specificity of Carcinoembryonic antigen (CEA) in Broncho Alveolar Lavage Fluid (BALF) and serum of bronchogenic carcinoma.

SETTINGS AND DESIGN

Case-Control study was conducted in the Medical College Hospital during a period of 2 years.

METHODS AND MATERIAL

We randomly selected 50 cases and 50 controls subjects. Cases were the patients with proven malignancy by biopsy or cytology, and controls were other non-malignant pulmonary diseases. All patients' CEA of Broncho Alveolar Lavage Fluid and serum was done.

STATISTICAL ANALYSIS

The mean and receiver operating curve were done for CEA of serum and BAL fluid, and based on the cut-off values, sensitivity and specificity were calculated.

RESULTS

Mean value of CEA in both BALF and serum in non-smoker patients of the malignant lesion was significantly higher than the non-malignant lesion. Mean value of CEA in both BALF and serum in smoker patients of the malignant lesion was higher than the benign lesion, but statistically not significant. The cut-off value for Serum CEA is 1μg/l, whereas for BALF CEA is 2μg/l. Sensitivity, specificity of CEA of Serum and BALF combined were 92% and 62% respectively.

CONCLUSIONS

Determination of CEA in the BALF and serum may be helpful as a screening tool for further workup for malignancy.

摘要

背景

生物标志物可用于肺癌筛查，临床医生可据此决定是否进行进一步的侵入性检查以明确诊断。

目的

了解癌胚抗原（CEA）在支气管肺泡灌洗液（BALF）和支气管源性肺癌患者血清中的诊断敏感性和特异性。

研究地点和设计

在医学院附属医院进行了一项为期2年的病例对照研究。

方法和材料

我们随机选取了50例病例和50例对照。病例为经活检或细胞学检查确诊为恶性肿瘤的患者，对照为其他非恶性肺部疾病患者。对所有患者的支气管肺泡灌洗液和血清进行CEA检测。

统计分析

对血清和BALF中的CEA进行均值和受试者工作曲线分析，并根据临界值计算敏感性和特异性。

结果

恶性病变的非吸烟患者BALF和血清中CEA的均值显著高于非恶性病变患者。恶性病变的吸烟患者BALF和血清中CEA的均值高于良性病变患者，但差异无统计学意义。血清CEA的临界值为1μg/l，而BALF CEA的临界值为2μg/l。血清和BALF联合检测CEA的敏感性和特异性分别为92%和62%。

结论

检测BALF和血清中的CEA可能有助于作为进一步检查恶性肿瘤的筛查工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/540a/6559055/f75dda02ae76/JFMPC-8-1725-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/540a/6559055/f75dda02ae76/JFMPC-8-1725-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/540a/6559055/f75dda02ae76/JFMPC-8-1725-g001.jpg

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