线粒体热休克蛋白TRAP1在癌症干细胞代谢与调控中的既往、当前及新出现的作用
Past, present, and emerging roles of mitochondrial heat shock protein TRAP1 in the metabolism and regulation of cancer stem cells.
作者信息
Im Chang-Nim
机构信息
Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Korea.
Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Korea.
出版信息
Cell Stress Chaperones. 2016 Jul;21(4):553-62. doi: 10.1007/s12192-016-0687-3. Epub 2016 Apr 12.
Abstract
Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member of the HSP90 family, controls a variety of physiological functions, including cell proliferation, differentiation, and survival. Most studies have been devoted to understanding the anti-apoptotic roles of TRAP1 in cancer and targeting it for tumor control in clinical settings. Additionally, we have identified a new role for TRAP1 in regulation of liver regeneration after partial hepatectomy in TRAP1 transgenic mice and cellular proliferation in TRAP1-overexpressing cells, via mitochondrial alterations. Moreover, recent works have indicated a role for TRAP1 in the regulation of cancer stem cells (CSCs) as well as a metabolic switch between mitochondrial respiration and aerobic glycolysis called as "Warburg effect." This review discusses the implications of TRAP1 action for both metabolism and the regulation of CSCs.
摘要
肿瘤坏死因子受体相关蛋白1（TRAP1）是热休克蛋白90（HSP90）家族的成员之一，可控制多种生理功能，包括细胞增殖、分化和存活。大多数研究致力于了解TRAP1在癌症中的抗凋亡作用，并将其作为临床环境中肿瘤控制的靶点。此外，我们已经确定TRAP1在TRAP1转基因小鼠部分肝切除术后肝再生调节以及TRAP1过表达细胞的细胞增殖中，通过线粒体改变发挥新作用。此外，最近的研究表明TRAP1在癌症干细胞（CSC）的调节中发挥作用，以及在称为“瓦伯格效应”的线粒体呼吸与有氧糖酵解之间的代谢转换中发挥作用。本综述讨论了TRAP1作用对代谢和CSC调节的影响。
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