Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Cancer Invest. 2012 Oct;30(8):552-9. doi: 10.3109/07357907.2012.716470. Epub 2012 Aug 21.
Published evidence concerning association of CYP1A12A (MspI) variation with oral carcinoma risk has generated controversial results. Our previous meta-analysis in 2008 failed to reveal a marked association between CYP1A12A polymorphism and oral cancer susceptibility. Therefore, updated meta-analyses were conducted. Results suggested significant associations between CYP1A12A polymorphisms and oral carcinoma risk for the overall data, inconsistent with our previous meta-analysis. In subgroup analyses by ethnicity, variant C allele might elevate oral cancer susceptibility among Asians but not Caucasians. In conclusion, results suggest that CYP1A12A polymorphism might be a low-penetrant risk factor for oral carcinoma, particularly among Asians.
已发表的关于 CYP1A12A（MspI）变异与口腔癌风险关联的证据产生了有争议的结果。我们 2008 年的荟萃分析未能显示 CYP1A12A 多态性与口腔癌易感性之间存在明显关联。因此，进行了更新的荟萃分析。结果表明，CYP1A12A 多态性与口腔癌风险之间存在显著关联，这与我们之前的荟萃分析不一致。按种族亚组分析，变异 C 等位基因可能会增加亚洲人群但不会增加白种人群的口腔癌易感性。总之，结果表明 CYP1A12A 多态性可能是口腔癌的一个低外显率风险因素，尤其是在亚洲人群中。
