Department of Medicine, School of Medicine, Jeju National University, Jeju 690-756, Korea.
Eur J Dermatol. 2010 Jan-Feb;20(1):42-8. doi: 10.1684/ejd.2010.0807. Epub 2009 Oct 12.
This study was conducted to evaluate the effect of Crinum asiaticum, a plant native to Jeju Island, Korea, on the promotion of hair growth. When rat vibrissa follicles were treated with a 95% ethanol (EtOH) extract of C. asiaticum, the hair-fiber lengths of the vibrissa follicles increased significantly. In addition, after daily topical application of the EtOH extract of C. asiaticum onto the back of C57BL/6 mice, anagen progression of the hair shaft was induced. Moreover, the extract increased the proliferation of immortalized vibrissa dermal papilla cells. When the vibrissa follicles in the anagen phase were treated with the extract, immunohistochemical analysis revealed that the extract was found to increase the expression of proliferating cell nuclear antigen (PCNA) in the bulb region of the 7-day cultured follicles. In particular, norgalanthamine, a principal of the extract, showed activity that increased the hair-fiber lengths of vibrissa follicles and the proliferation of dermal papilla cells. These results suggest that norgalanthamine, a principal of C. asiaticum, has the potential to promote hair growth via the proliferation of dermal papilla.
本研究旨在评估原产于韩国济州岛的百合科植物文殊兰对促进毛发生长的作用。当大鼠触须毛囊用文殊兰的 95%乙醇（EtOH）提取物处理时，触须毛囊的毛纤维长度显著增加。此外，每日将文殊兰 EtOH 提取物涂于 C57BL/6 小鼠背部后，可诱导毛干进入生长期。此外，提取物可增加永生化触须真皮乳头细胞的增殖。当处于生长期的毛囊被提取物处理时，免疫组织化学分析显示，提取物可增加培养 7 天的毛囊球部中增殖细胞核抗原（PCNA）的表达。特别是，文殊兰提取物中的主要成分山莨菪碱具有增加触须毛囊毛纤维长度和真皮乳头细胞增殖的活性。这些结果表明，文殊兰的主要成分山莨菪碱可能通过真皮乳头细胞的增殖来促进毛发生长。
