Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Eur Rev Med Pharmacol Sci. 2017 Nov;21(21):4784-4789.
Osteoporosis (OP) is a kind of disease with a 25% incidence, characterized by the bone mass loss, bone microstructure damage, increased bone fragility, and easy fracture. miRNA plays an important regulatory role in the process of bone remodeling, especially in the regulation of differentiation and function of osteoblasts and osteoclasts, and the development and progression of OP and other bone diseases. In the future, it is expected to delay the bone loss and promote the bone remodeling via the overexpression or inhibition of specific miRNAs in specific tissues, thereby treating OP.
骨质疏松症（OP）是一种发病率为 25%的疾病，其特征是骨量丢失、骨微观结构损伤、骨脆性增加和易骨折。miRNA 在骨重塑过程中发挥着重要的调节作用，特别是在调节成骨细胞和破骨细胞的分化和功能，以及 OP 和其他骨疾病的发展和进展方面。未来，有望通过在特定组织中过表达或抑制特定的 miRNAs 来延迟骨丢失并促进骨重塑，从而治疗 OP。
