Wang Tao, Zhang Chao, Xu Lin, Li Xingnuan
Key Laboratory of System Bio-Medicine of Jiangxi Province, Jiujiang University, Jiujiang, China.
Affiliated Hospital of Jiujiang University, Jiujiang, China.
Biofactors. 2024 Jan-Feb;50(1):6-15. doi: 10.1002/biof.1994. Epub 2023 Aug 3.
The process of bone remodeling occurs and is regulated through interactions between osteoclasts, which resorb bone, and osteoblasts, which generate bone tissue. When the homeostatic balance between these two cell types is dysregulated, this can contribute to abnormal bone remodeling resulting in a loss of bone mass as is observed in osteoporosis (OP) and other forms of degenerative bone metabolic diseases. At present, details of molecular mechanism underlying the development of bone metabolic diseases such as OP remain to be elucidated. Circular RNAs (circRNAs) are small non-coding RNA molecules with a closed-loop structure that can regulate the differentiation of osteoclasts and osteoblasts. The present review provides a systematic overview of recent literature on the processes through which circRNAs regulate the dynamic balance between osteoblasts and osteoclasts that ultimately preserve bone homeostasis. It will also give insight that can shape current understanding of the pathogenesis of OP and other bone metabolic diseases to better guide diagnostic and treatment strategies for affected patients.
骨重塑过程通过破骨细胞（吸收骨组织）和成骨细胞（生成骨组织）之间的相互作用而发生并受到调节。当这两种细胞类型之间的稳态平衡失调时，可能会导致异常的骨重塑，进而导致骨量流失，如在骨质疏松症（OP）和其他形式的退行性骨代谢疾病中所观察到的那样。目前，OP等骨代谢疾病发生发展的分子机制细节仍有待阐明。环状RNA（circRNAs）是具有闭环结构的小型非编码RNA分子，可调节破骨细胞和成骨细胞的分化。本综述系统概述了近期有关circRNAs调节成骨细胞和破骨细胞之间动态平衡（最终维持骨稳态）过程的文献。它还将提供见解，以塑造目前对OP和其他骨代谢疾病发病机制的理解，从而更好地指导受影响患者的诊断和治疗策略。
