Liu Shi, Wu Yu, Wooten H Omar, Green Olga, Archer Brent, Li Harold, Yang Deshan
School of Medicine, Washington University in St. Louis.
J Appl Clin Med Phys. 2016 Mar 8;17(2):50-62. doi: 10.1120/jacmp.v17i2.5907.
A software tool is developed, given a new treatment plan, to predict treatment delivery time for radiation therapy (RT) treatments of patients on ViewRay magnetic resonance image-guided radiation therapy (MR-IGRT) delivery system. This tool is necessary for managing patient treatment scheduling in our clinic. The predicted treatment delivery time and the assessment of plan complexities could also be useful to aid treatment planning. A patient's total treatment delivery time, not including time required for localization, is modeled as the sum of four components: 1) the treatment initialization time; 2) the total beam-on time; 3) the gantry rotation time; and 4) the multileaf collimator (MLC) motion time. Each of the four components is predicted separately. The total beam-on time can be calculated using both the planned beam-on time and the decay-corrected dose rate. To predict the remain-ing components, we retrospectively analyzed the patient treatment delivery record files. The initialization time is demonstrated to be random since it depends on the final gantry angle of the previous treatment. Based on modeling the relationships between the gantry rotation angles and the corresponding rotation time, linear regression is applied to predict the gantry rotation time. The MLC motion time is calculated using the leaves delay modeling method and the leaf motion speed. A quantitative analysis was performed to understand the correlation between the total treatment time and the plan complexity. The proposed algorithm is able to predict the ViewRay treatment delivery time with the average prediction error 0.22min or 1.82%, and the maximal prediction error 0.89 min or 7.88%. The analysis has shown the correlation between the plan modulation (PM) factor and the total treatment delivery time, as well as the treatment delivery duty cycle. A possibility has been identified to significantly reduce MLC motion time by optimizing the positions of closed MLC pairs. The accuracy of the proposed prediction algorithm is sufficient to support patient treatment appointment scheduling. This developed software tool is currently applied in use on a daily basis in our clinic, and could also be used as an important indicator for treatment plan complexity.
开发了一种软件工具,给定新的治疗计划,可预测在ViewRay磁共振图像引导放射治疗(MR-IGRT)输送系统上对患者进行放射治疗(RT)的治疗交付时间。该工具对于管理我们诊所的患者治疗安排很有必要。预测的治疗交付时间和计划复杂性评估对于辅助治疗计划也可能有用。患者的总治疗交付时间(不包括定位所需时间)被建模为四个部分的总和:1)治疗初始化时间;2)总束流开启时间;3)机架旋转时间;4)多叶准直器(MLC)运动时间。这四个部分分别进行预测。总束流开启时间可使用计划束流开启时间和衰变校正剂量率来计算。为了预测其余部分,我们回顾性分析了患者治疗交付记录文件。初始化时间被证明是随机的,因为它取决于前一次治疗的最终机架角度。基于对机架旋转角度与相应旋转时间之间关系的建模,应用线性回归来预测机架旋转时间。MLC运动时间使用叶片延迟建模方法和叶片运动速度来计算。进行了定量分析以了解总治疗时间与计划复杂性之间的相关性。所提出的算法能够预测ViewRay治疗交付时间,平均预测误差为0.22分钟或1.82%,最大预测误差为0.89分钟或7.88%。分析表明了计划调制(PM)因子与总治疗交付时间以及治疗交付占空比之间的相关性。已确定通过优化关闭的MLC对的位置可显著减少MLC运动时间。所提出的预测算法的准确性足以支持患者治疗预约安排。这个开发的软件工具目前在我们诊所每天都在使用,也可作为治疗计划复杂性的重要指标。