Allergy and Lung Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, the University of Melbourne, Carlton, Australia.
Biostatistics Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, the University of Melbourne, Carlton, Australia.
Eur Respir J. 2016 Jul;48(1):125-32. doi: 10.1183/13993003.01598-2015. Epub 2016 Apr 13.
The objective was to assess associations between duration of total and exclusive breastfeeding and lung function up to adolescence.A birth cohort (Melbourne Atopy Cohort Study) of 620 infants with a family history of allergic disease was recruited. Mothers were encouraged to breastfeed exclusively for 6 months. Lung function was assessed at 12 and 18 years of age. Associations between breastfeeding and lung function were investigated using multivariable linear regression and path analysis was used to assess the potential mediating factors.Duration of breastfeeding (total and exclusive) was not associated with most assessed lung function outcomes. However, there was a trend for increased pre-bronchodilator mid-expiratory flow (MEF) at both 12 (adjusted mean difference (95% CI) per week of breastfeeding of 10 (-1-20) mL·s(-1)) and 18 years (11 (-1-22) mL·s(-1)) (p-values of 0.07 and 0.08, respectively). There was a strong indirect effect of height on these observed associations.Duration of breastfeeding does not appear to greatly influence lung function outcomes in children with a family history of allergic diseases. Longer duration of exclusive breastfeeding may be associated with an increase in MEF, partly due to greater attained height of the child.
目的是评估母乳喂养总时长和纯母乳喂养时长与青少年期肺功能之间的关联。研究纳入了一个具有过敏疾病家族史的 620 名婴儿的出生队列（墨尔本过敏队列研究）。鼓励母亲进行纯母乳喂养 6 个月。在 12 岁和 18 岁时评估肺功能。使用多变量线性回归分析母乳喂养与肺功能之间的关系，并使用路径分析评估潜在的中介因素。母乳喂养（总时长和纯母乳喂养时长）与大多数评估的肺功能结果无关。然而，在 12 岁（调整后的每周母乳喂养差异（95%CI）为 10（-1-20）mL·s(-1))和 18 岁（11（-1-22）mL·s(-1)))时，支气管扩张前中呼气流量（MEF）有增加的趋势（p 值分别为 0.07 和 0.08）。身高对这些观察到的关联有很强的间接影响。对于有过敏疾病家族史的儿童，母乳喂养的时长似乎不会极大地影响肺功能结果。更长时间的纯母乳喂养可能与 MEF 的增加有关，部分原因是儿童的身高增长更大。
