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[脑膜瘤:最常见脑肿瘤的治疗]

[Meningioma: management of the most common brain tumour].

作者信息

Hundsberger Thomas, Surbeck Werner, Hader Claudia, Putora Paul Martin, Conen Katrin, Roelcke Ulrich

机构信息

1 Klinik für Neurologie, Kantonsspital St. Gallen.

2 Klinik für Hämatologie und Onkologie, Kantonsspital St. Gallen.

出版信息

Praxis (Bern 1994). 2016 Apr 13;105(8):445-51. doi: 10.1024/1661-8157/a002320.

Abstract

Meningiomas are the most common primary brain tumours in adults and are therefore relevant for general practitioners. Most meningiomas are benign and neurosurgical resection offers the best chance of cure. However, complete resection is not achievable in many patients. This accounts for a relevant rate of tumour recurrences within 15 years of follow up. In atypical and anaplastic meningiomas of WHO grade II and III time to recurrence is dramatically shorter and these tumours need multimodal treatment strategies including postoperative radiotherapy. Various systemic treatments have occasionally been used as salvage therapy, but were essentially not effective. Only recently, Sunitinib, a small thyrosine kinase inhibitor as well as bevacizumab, a therapeutic antibody, have shown more promising results in highly pretreated, refractory meningioma patients.

摘要

脑膜瘤是成人中最常见的原发性脑肿瘤,因此对全科医生来说很重要。大多数脑膜瘤是良性的,神经外科手术切除提供了最佳的治愈机会。然而,许多患者无法实现完全切除。这导致了随访15年内肿瘤复发率较高。对于世界卫生组织II级和III级的非典型和间变性脑膜瘤,复发时间明显更短,这些肿瘤需要多模式治疗策略,包括术后放疗。各种全身治疗偶尔被用作挽救治疗,但基本上无效。直到最近,小分子酪氨酸激酶抑制剂舒尼替尼以及治疗性抗体贝伐单抗,在经过高度预处理的难治性脑膜瘤患者中显示出更有希望的结果。

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