Konstantinou Froso, Potaris Konstantinos, Syrigos Konstantinos N, Tsipas Panteleimon, Karagkiouzis Grigorios, Konstantinou Marios
Oncology Unit, 3rd Internal Medicine Clinic of Athens University, Sotiria General Hospital, Athens, Greece.
Department of Thoracic Surgery, 3rd Internal Medicine Clinic of Athens University, Sotiria General Hospital, Athens, Greece.
Med Sci Monit. 2016 Apr 15;22:1258-64. doi: 10.12659/msm.895134.
BACKGROUND Persistent air leak following pulmonary lobectomy can be very difficult to treat and results in prolonged hospitalization. We aimed to evaluate the efficacy of a new method of postoperative air leak management using intrapleurally infused fresh frozen plasma via the chest tube. MATERIAL AND METHODS Between June 2008 and June 2014, we retrospectively reviewed 98 consecutive patients who underwent lobectomy for lung cancer and postoperatively developed persistent air leak treated with intrapleural instillation of fresh frozen plasma. RESULTS The study identified 89 men and 9 women, with a median age of 65.5 years (range 48-77 years), with persistent postoperative air leak. Intrapleural infusion of fresh frozen plasma was successful in stopping air leaks in 90 patients (92%) within 24 hours, and in 96 patients (98%) within 48 hours, following resumption of the procedure. In the remaining 2, air leak ceased at 14 and 19 days. CONCLUSIONS Intrapleural infusion of fresh frozen plasma is a safe, inexpensive, and remarkably effective method for treatment of persistent air leak following lobectomy for lung cancer.
肺叶切除术后持续性漏气很难治疗，会导致住院时间延长。我们旨在评估一种通过胸管向胸腔内注入新鲜冰冻血浆来管理术后漏气的新方法的疗效。
2008年6月至2014年6月期间，我们回顾性分析了98例连续接受肺癌肺叶切除术且术后出现持续性漏气并接受胸腔内注入新鲜冰冻血浆治疗的患者。
该研究纳入了89例男性和9例女性，中位年龄为65.5岁（范围48 - 77岁），术后存在持续性漏气。胸腔内注入新鲜冰冻血浆后，90例患者（92%）在24小时内漏气停止，96例患者（98%）在恢复该操作后的48小时内漏气停止。其余2例患者分别在14天和19天时漏气停止。
胸腔内注入新鲜冰冻血浆是治疗肺癌肺叶切除术后持续性漏气的一种安全、廉价且非常有效的方法。
