Maestri Elena, Marmiroli Marta, Marmiroli Nelson
Department of Life Sciences, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy; SITEIA, PARMA, Interdepartmental Centre for Food Safety, Technologies and Innovation for Agri-food, Parco Area delle Scienze, 43124 Parma, Italy.
Department of Life Sciences, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
J Proteomics. 2016 Sep 16;147:140-155. doi: 10.1016/j.jprot.2016.03.048. Epub 2016 Apr 11.
A literature survey covering the presence of bioactive peptides in plant-derived foodstuffs is presented. Examples are given of plant peptides associated with a beneficial effect on human health. The main bioactive effects of these peptides are defined and their mechanism of action described, when known. Current understanding of the way in which these molecules are adsorbed, distributed, metabolized and finally excreted is discussed. A particular focus is given to potentially immunomodulatory peptides. The leading analytical assay methods used to evaluate their activity are outlined. Inspection of crop proteomic data revealed that at least 6000 proteins may harbour bioactive peptides. The analysis of these proteins using a Gene Ontology approach has provided a number of insights regarding their occurrence and relevance.
The review reports an updated survey on bioactive peptides present in food crop plants, with a particular focus on immunomodulatory peptides which might be relevant for therapeutic applications. It employs a bioinformatic approach to search for proteins of crop plants potentially harboring bioactive peptides, summarising through Gene Ontology the main classes of peptide-containing proteins in food.
本文对植物源食品中生物活性肽的存在情况进行了文献综述。列举了对人体健康有有益作用的植物肽实例。定义了这些肽的主要生物活性作用，并在已知的情况下描述了其作用机制。讨论了目前对这些分子的吸附、分布、代谢及最终排泄方式的理解。特别关注了潜在的免疫调节肽。概述了用于评估其活性的主要分析检测方法。对作物蛋白质组学数据的检查表明，至少有6000种蛋白质可能含有生物活性肽。使用基因本体论方法对这些蛋白质进行分析，提供了一些关于它们的出现情况和相关性的见解。
本综述报告了对粮食作物中存在的生物活性肽的最新调查，特别关注可能与治疗应用相关的免疫调节肽。它采用生物信息学方法搜索可能含有生物活性肽的作物蛋白质，通过基因本体论总结食品中含肽蛋白质的主要类别。
