Institute for Food Technology and Biochemistry, Faculty of Agriculture, University of Belgrade, Serbia.
University of Parma, Department of Chemistry, Life Sciences and Environmental Sustainability, and Interdepartmental Center SITEIA.PARMA, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Peptides. 2022 Feb;148:170696. doi: 10.1016/j.peptides.2021.170696. Epub 2021 Nov 29.
Immunomodulatory peptides are a complex class of bioactive peptides that encompasses substances with different mechanisms of action. Immunomodulatory peptides could also be used in vaccines as adjuvants which would be extremely desirable, especially in response to pandemics. Thus, immunomodulatory peptides in food of plant origin could be regarded both as valuable suplements of novel functional food preparation and/or as precursors or possible active ingredients for drugs design for treatment variety of conditions arising from impaired function of immune system. Given variety of mechanisms, different tests are required to assess effects of immunomodulatory peptides. Some of those effects show good correlation with in vivo results but others, less so. Certain plant peptides, such as defensins, show both immunomodulatory and antimicrobial effect, which makes them interesting candidates for preparation of functional food and feed, as well as templates for design of synthetic peptides.
免疫调节肽是一类具有复杂生物活性的肽类物质，包含具有不同作用机制的物质。免疫调节肽也可以作为疫苗佐剂使用，这是非常理想的，尤其是在应对大流行时。因此，植物源性食品中的免疫调节肽既可以作为新型功能性食品制备的有价值的补充剂，也可以作为药物设计的前体或可能的活性成分，用于治疗因免疫系统功能障碍而引起的各种疾病。鉴于其多种作用机制，需要进行不同的测试来评估免疫调节肽的作用。其中一些作用与体内结果具有良好的相关性，而其他作用则不然。某些植物肽，如防御素，具有免疫调节和抗菌作用，这使它们成为功能性食品和饲料制备的候选物质，也是合成肽设计的模板。
