Area of Cell and Developmental Biology, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain.
Area of Cell and Developmental Biology, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain.
Trends Immunol. 2016 May;37(5):334-345. doi: 10.1016/j.it.2016.03.005. Epub 2016 Apr 12.
Neutrophils are first-responders, providing early protection against invading pathogens. Recent findings have revealed a temporal dimension to neutrophil function, associated with the clearance cycles for aging neutrophils, and also with a program that endows circulating neutrophils with distinct phenotypic and functional properties at different times of the day, before they are cleared from blood. We review here the process of neutrophil aging and its impact on homeostasis and inflammation. We outline the features of aged neutrophils, examine proposed mechanisms that drive aging, and discuss how these processes may contribute to tissue homeostasis and pathology. In this context we propose that neutrophil aging may optimize host defense by allowing neutrophils to anticipate infections while avoiding permanent activation and subsequent damage.
中性粒细胞是“一线反应者”，为抵御入侵病原体提供早期保护。最近的研究发现，中性粒细胞的功能具有时间维度，与衰老中性粒细胞的清除周期有关，也与一个程序有关，该程序在循环中性粒细胞从血液中清除之前，赋予它们在一天中的不同时间具有独特的表型和功能特性。我们在这里回顾了中性粒细胞衰老的过程及其对体内平衡和炎症的影响。我们概述了衰老中性粒细胞的特征，检查了驱动衰老的拟议机制，并讨论了这些过程如何有助于组织体内平衡和病理学。在这种情况下，我们提出中性粒细胞衰老可以通过允许中性粒细胞在避免永久性激活和随后的损伤的同时预测感染，从而优化宿主防御。
