Agardh Emilie E, Danielsson Anna-Karin, Ramstedt Mats, Ledgaard Holm Astrid, Diderichsen Finn, Juel Knud, Vollset Stein Emil, Knudsen Ann Kristin, Minet Kinge Jonas, White Richard, Skirbekk Vegard, Mäkelä Pia, Forouzanfar Mohammad Hossein, Coates Matthew M, Casey Daniel C, Naghavi Mohesen, Allebeck Peter
Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Swedish Council for Information on Alcohol and Drugs (CAN), Stockholm, Sweden.
Addiction. 2016 Oct;111(10):1806-13. doi: 10.1111/add.13430. Epub 2016 Jun 6.
(1) To compare alcohol-attributed disease burden in four Nordic countries 1990-2013, by overall disability-adjusted life years (DALYs) and separated by premature mortality [years of life lost (YLL)] and health loss to non-fatal conditions [years lived with disability (YLD)]; (2) to examine whether changes in alcohol consumption informs alcohol-attributed disease burden; and (3) to compare the distribution of disease burden separated by causes.
A comparative risk assessment approach.
Sweden, Norway, Denmark and Finland.
Male and female populations of each country.
Age-standardized DALYs, YLLs and YLDs per 100 000 with 95% uncertainty intervals (UIs).
In Finland, with the highest burden over the study period, overall alcohol-attributed DALYs were 1616 per 100 000 in 2013, while in Norway, with the lowest burden, corresponding estimates were 634. DALYs in Denmark were 1246 and in Sweden 788. In Denmark and Finland, changes in consumption generally corresponded to changes in disease burden, but not to the same extent in Sweden and Norway. All countries had a similar disease pattern and the majority of DALYs were due to YLLs (62-76%), mainly from alcohol use disorder, cirrhosis, transport injuries, self-harm and violence. YLDs from alcohol use disorder accounted for 41% and 49% of DALYs in Denmark and Finland compared to 63 and 64% in Norway and Sweden 2013, respectively.
Finland and Denmark has a higher alcohol-attributed disease burden than Sweden and Norway in the period 1990-2013. Changes in consumption levels in general corresponded to changes in harm in Finland and Denmark, but not in Sweden and Norway for some years. All countries followed a similar pattern. The majority of disability-adjusted life years were due to premature mortality. Alcohol use disorder by non-fatal conditions accounted for a higher proportion of disability-adjusted life years in Norway and Sweden, compared with Finland and Denmark.
(1)通过总体残疾调整生命年(DALYs),并按过早死亡率[寿命损失年数(YLL)]和非致命状况导致的健康损失[残疾生存年数(YLD)]进行划分,比较1990 - 2013年四个北欧国家酒精所致疾病负担;(2)研究酒精消费的变化是否能反映酒精所致疾病负担;(3)比较按病因划分的疾病负担分布情况。
一种比较风险评估方法。
瑞典、挪威、丹麦和芬兰。
每个国家的男性和女性人群。
每10万人的年龄标准化DALYs、YLLs和YLDs,并带有95%的不确定性区间(UIs)。
在研究期间负担最高的芬兰,2013年酒精所致总体DALYs为每10万人1616例,而负担最低的挪威,相应估计值为634例。丹麦的DALYs为1246例,瑞典为788例。在丹麦和芬兰,消费变化通常与疾病负担变化相对应,但在瑞典和挪威并非如此。所有国家都有相似的疾病模式,且大多数DALYs归因于YLLs(62 - 76%),主要源于酒精使用障碍、肝硬化、交通伤害、自残和暴力行为。2013年,丹麦和芬兰因酒精使用障碍导致的YLDs分别占DALYs的41%和49%,而挪威和瑞典分别为63%和64%。
1990 - 2013年期间,芬兰和丹麦的酒精所致疾病负担高于瑞典和挪威。总体而言,芬兰和丹麦的消费水平变化与危害变化相对应,但在某些年份瑞典和挪威并非如此。所有国家都呈现相似模式。大多数残疾调整生命年归因于过早死亡。与芬兰和丹麦相比,挪威和瑞典非致命状况下的酒精使用障碍在残疾调整生命年中所占比例更高。