Chen Y, Shimotake A, Matsumoto R, Kunieda T, Kikuchi T, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A, Lambon Ralph M A
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester, UK.
Department of Neurology, Graduate School of Medicine, Kyoto University, Japan.
Cortex. 2016 Jun;79:1-13. doi: 10.1016/j.cortex.2016.02.015. Epub 2016 Mar 16.
Electrocorticograms (ECoG) provide a unique opportunity to monitor neural activity directly at the cortical surface. Ten patients with subdural electrodes covering ventral and lateral anterior temporal regions (ATL) performed a picture naming task. Temporal representational similarity analysis (RSA) was used, for the first time, to compare spatio-temporal neural patterns from the ATL surface with pre-defined theoretical models. The results indicate that the neural activity in the ventral subregion of the ATL codes semantic representations from 250 msec after picture onset. The observed activation similarity was not related to the visual similarity of the pictures or the phonological similarity of their names. In keeping with convergent evidence for the importance of the ATL in semantic processing, these results provide the first direct evidence of semantic coding from the surface of the ventral ATL and its time-course.
皮质电图（ECoG）提供了一个在皮质表面直接监测神经活动的独特机会。十名患有覆盖腹侧和外侧前颞叶区域（ATL）的硬膜下电极的患者执行了图片命名任务。首次使用颞部表征相似性分析（RSA），将来自ATL表面的时空神经模式与预定义的理论模型进行比较。结果表明，ATL腹侧子区域的神经活动在图片出现后250毫秒开始编码语义表征。观察到的激活相似性与图片的视觉相似性或其名称的语音相似性无关。与关于ATL在语义处理中重要性的趋同证据一致，这些结果提供了腹侧ATL表面语义编码及其时间进程的首个直接证据。
