黑色素瘤的现状：挑战与机遇
The state of melanoma: challenges and opportunities.
作者信息
Merlino Glenn, Herlyn Meenhard, Fisher David E, Bastian Boris C, Flaherty Keith T, Davies Michael A, Wargo Jennifer A, Curiel-Lewandrowski Clara, Weber Michael J, Leachman Sancy A, Soengas Maria S, McMahon Martin, Harbour J William, Swetter Susan M, Aplin Andrew E, Atkins Michael B, Bosenberg Marcus W, Dummer Reinhard, Gershenwald Jeffrey E, Halpern Allan C, Herlyn Dorothee, Karakousis Giorgos C, Kirkwood John M, Krauthammer Michael, Lo Roger S, Long Georgina V, McArthur Grant, Ribas Antoni, Schuchter Lynn, Sosman Jeffrey A, Smalley Keiran S, Steeg Patricia, Thomas Nancy E, Tsao Hensin, Tueting Thomas, Weeraratna Ashani, Xu George, Lomax Randy, Martin Alison, Silverstein Steve, Turnham Tim, Ronai Ze'ev A
机构信息
Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA.
出版信息
Pigment Cell Melanoma Res. 2016 Jul;29(4):404-16. doi: 10.1111/pcmr.12475. Epub 2016 Apr 17.
The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas - diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts as per the current status, challenges, and opportunities in the four respective areas. The current state and immediate and long-term needs of the melanoma field, from basic research to clinical management, are presented in the following report.
黑色素瘤研究基金会（MRF）对黑色素瘤研究与治疗的现状进行了全面评估。MRF科学顾问委员会成员与突破联盟（该联盟成员包括临床医生和科学家）进行了深入讨论，重点围绕四个主题领域展开——诊断/早期检测、预防、肿瘤细胞休眠（包括转移）以及治疗（反应与耐药性）。这些讨论贯穿了2015年全年，并于11月在黑色素瘤研究学会2015年国际大会上达到高潮。四个小组中的每一组都根据各自领域的现状、挑战和机遇阐述了他们的想法。以下报告呈现了黑色素瘤领域从基础研究到临床管理的现状以及近期和长期需求。
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