氧化应激：化学预防的一个有前景的靶点。
Oxidative Stress: A Promising Target for Chemoprevention.
作者信息
John Am Sashi Papu, Ankem Murali K, Damodaran Chendil
机构信息
Department of Urology, University of Louisville, KY 40202.
出版信息
Curr Pharmacol Rep. 2016 Apr;2(2):73-81. doi: 10.1007/s40495-016-0052-3. Epub 2016 Feb 5.
Abstract
Cancer is a leading cause of death worldwide, and treating advanced stages of cancer remains clinically challenging. Epidemiological studies have shown that oxidants and free radicals induced DNA damage is one of the predominant causative factors for cancer pathogenesis. Hence, oxidants are attractive targets for chemoprevention as well as therapy. Dietary agents are known to exert an anti-oxidant property which is one of the most efficient preventive strategy in cancer progression. In this article, we highlight dietary agents can potentially target oxidative stress, in turn delaying, preventing, or treating cancer development. Some of these agents are currently in use in basic research, while some have been launched successfully into clinical trials.
摘要
癌症是全球主要的死亡原因之一，治疗癌症晚期在临床上仍然具有挑战性。流行病学研究表明，氧化剂和自由基诱导的DNA损伤是癌症发病的主要致病因素之一。因此，氧化剂是化学预防和治疗的有吸引力的靶点。已知膳食剂具有抗氧化特性，这是癌症进展中最有效的预防策略之一。在本文中，我们强调膳食剂可能靶向氧化应激，进而延缓、预防或治疗癌症发展。其中一些制剂目前正在基础研究中使用，而一些已经成功进入临床试验。
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2
An insight into the potentially old-wonder molecule-quercetin: the perspectives in foresee.对潜在的古老神奇分子——槲皮素的洞察：可预见的前景。
Chin J Integr Med. 2015 Sep 9:1-16. doi: 10.1007/s11655-015-2073-x.
3
Quercetin reduces Ehrlich tumor-induced cancer pain in mice.槲皮素可减轻小鼠艾氏腹水癌诱发的癌痛。
Anal Cell Pathol (Amst). 2015;2015:285708. doi: 10.1155/2015/285708. Epub 2015 Aug 13.
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Apoptosis. 2015 Nov;20(11):1420-32. doi: 10.1007/s10495-015-1150-0.
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