Waage Christin W, Mdala Ibrahimu, Jenum Anne Karen, Michelsen Trond M, Birkeland Kåre I, Sletner Line
aDepartment of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital bFaculty of Medicine, University of Oslo, Institute of Health and Society cSection for Obstetrics, Women and Children's Division, Oslo University Hospital Rikshospitalet dNorwegian National Advisory Unit on Women's Health, Oslo University Hospital eInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo fDepartment of Child and Adolescents Medicine, Akershus University Hospital, Lørenskog, Norway.
J Hypertens. 2016 Jun;34(6):1151-9. doi: 10.1097/HJH.0000000000000918.
To examine blood pressure (BP) differences and changes between and within ethnic Western European, South Asian, Middle Eastern, East Asian, African, and East European living in Norway, from early pregnancy to postpartum and to explore associations between BP and explanatory variables.
This was a population-based cohort study of 811 healthy pregnant women, 59% had ethnic minority origin. Participants were from Western Europe, Eastern Europe, South Asia, East Asia, Middle East, and Africa. We performed ANOVA, generalized estimating equations linear regression and multiple linear regression analysis.
At 15 weeks' gestation, mean SBP were 4.9-7.0 mmHg lower and mean DBP 2.1-3.4 mmHg lower for the non-Europeans compared with Western Europeans. SBP increased in all non-European groups from 15 weeks' gestation to 14 weeks' postpartum (P < 0.01), but not in Europeans. Ethnic differences were further reduced postpartum, with only South Asians having lower mean SBP than Western Europeans (P < 0.01). The ethnic differences persisted after adjusting for age, family history of cardiovascular disease, prepregnancy BMI, and prepregnancy physical activity. Age, prepregnancy BMI, prepregnancy physical activity, postpartum weight retention, and breastfeeding were independently associated with postpartum BP (P < 0.05).
Pregnancy may have a more adverse effect on BP trajectories from early pregnancy to postpartum among non-European women compared with Western Europeans, despite their more favorable BP in early pregnancy.
研究居住在挪威的西欧、南亚、中东、东亚、非洲和东欧族裔女性从妊娠早期到产后的血压差异及变化，并探讨血压与解释变量之间的关联。
这是一项基于人群的队列研究，纳入811名健康孕妇，其中59%为少数民族裔。参与者来自西欧、东欧、南亚、东亚、中东和非洲。我们进行了方差分析、广义估计方程线性回归和多元线性回归分析。
在妊娠15周时，与西欧女性相比，非欧洲女性的平均收缩压低4.9 - 7.0 mmHg，平均舒张压低2.1 - 3.4 mmHg。所有非欧洲组的收缩压从妊娠15周增加到产后14周（P < 0.01），而欧洲女性则没有。产后种族差异进一步缩小，只有南亚女性的平均收缩压低于西欧女性（P < 0.01）。在调整年龄、心血管疾病家族史、孕前体重指数和孕前身体活动后，种族差异仍然存在。年龄、孕前体重指数（BMI）、孕前身体活动、产后体重滞留和母乳喂养与产后血压独立相关（P < 0.05）。
与西欧女性相比，非欧洲女性从妊娠早期到产后，妊娠对血压轨迹可能有更不利的影响，尽管她们在妊娠早期血压更有利。
