Bradford Institute for Health Research, Bradford, UK.
MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Sci Rep. 2018 Jun 12;8(1):8966. doi: 10.1038/s41598-018-27316-1.
South Asians have higher rates of coronary heart disease (CHD) than White European individuals. Blood pressure (BP) is one of the most important risk factors for CHD and ethnic differences in BP have been identified in childhood. Early life exposures could explain some of these differences. We examined associations of family social and economic and maternal pregnancy exposures and BP at age 4/5 in 1644 White British and 1824 Pakistani mother-offspring pairs from the Born in Bradford study. We found that systolic BP was similar but diastolic BP was higher, in Pakistani compared to White British children (adjusted mean differences were -0.170 mmHg 95% CI -0.884, 0.543 for systolic BP; 1.328 mmHg 95% CI 0.592, 2.064 for diastolic BP). Social and economic exposures were not associated with BP in either ethnic group. Maternal BMI was positively associated with BP in both groups but this association was mediated by child BMI. Only gestational hypertension was associated with child systolic and diastolic BP and this was only identified in Pakistani mother-offspring pairs. These findings suggest that Pakistani populations may have a different BP trajectory compared to White British groups and that this is already evident at age 4/5 years.
南亚人患冠心病 (CHD) 的比率高于白种欧洲人。血压 (BP) 是 CHD 的最重要危险因素之一，在儿童时期已经确定了 BP 的种族差异。早期生活暴露可能可以解释其中的一些差异。我们在布拉德福德出生研究中检查了 1644 对白种英国人和 1824 对巴基斯坦母亲-子女对的家庭社会经济和母亲妊娠暴露与 4/5 岁时 BP 的关联。我们发现，与白种英国儿童相比，巴基斯坦儿童的收缩压相似但舒张压更高（调整后的平均差异为 -0.170mmHg，95%CI-0.884，0.543 用于收缩压；1.328mmHg，95%CI0.592，2.064 用于舒张压）。社会经济暴露与两组的 BP 均无关联。母亲 BMI 与两组的 BP 均呈正相关，但这种关联通过儿童 BMI 介导。只有妊娠高血压与儿童的收缩压和舒张压有关，而且仅在巴基斯坦母婴对子中发现。这些发现表明，与白种英国人群相比，巴基斯坦人群的 BP 轨迹可能不同，而且这种差异在 4/5 岁时就已经明显。
