Guo Weihong, Huen Karen, Park June-Soo, Petreas Myrto, Crispo Smith Sabrina, Block Gladys, Holland Nina
Environmental Chemistry Laboratory, California Department of Toxic Substances Control, 700 Heinz Ave, S. 100, Berkeley, CA 94710, USA.
School of Public Health, 50 University Hall, University of California, Berkeley, CA 94720, USA.
Food Chem Toxicol. 2016 Jun;92:197-204. doi: 10.1016/j.fct.2016.04.006. Epub 2016 Apr 23.
Emerging evidence suggests that exposure to endocrine-disrupting chemicals including persistent organic pollutants (POPs) such as organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) has a long term impact on human health. The goal of this pilot study was to test whether antioxidant intervention by vitamin C supplementation may be a remedial approach to decrease body burden of POPs in humans. Using solid phase extraction coupled with a triple quadrupole mass spectrometer and a gas chromatography high resolution mass spectrometry, we measured 18 PCBs, 7 OCPs, and 5 PBDEs in the blood of 15 healthy California women (8 were obese/overweight and 7 had normal weight) before and after 2 months of vitamin C supplementation (1000 mg/day). We observed higher PBDE levels than PCBs and OCPs, but only PCB and OCP levels were strongly and positively correlated with participant's BMI and age. We also found statistically significant decreases in 6 PCBs (PCB-74, PCB-118, PCB-138, PCB-153, PCB-180, and PCB-187), and 2 OCPs (4,4'-DDE, and 4,4'-DDT), but not PBDEs after vitamin C supplementation. Pending confirmation of this pilot finding in a larger study of both sexes, vitamin C intervention may have important public health implications in protecting health by reducing body burdens of POPs.
新出现的证据表明，接触包括持久性有机污染物（POPs）在内的内分泌干扰化学物质，如有机氯农药（OCPs）、多氯联苯（PCBs）和多溴二苯醚（PBDEs），会对人类健康产生长期影响。这项初步研究的目的是测试补充维生素C进行抗氧化干预是否可能是一种降低人体中POPs负担的补救方法。我们使用固相萃取结合三重四极杆质谱仪和气相色谱高分辨率质谱仪，在15名健康的加利福尼亚女性（8名肥胖/超重，7名体重正常）补充维生素C（1000毫克/天）2个月前后，测量了她们血液中的18种多氯联苯、7种有机氯农药和5种多溴二苯醚。我们观察到多溴二苯醚水平高于多氯联苯和有机氯农药，但只有多氯联苯和有机氯农药水平与参与者的体重指数和年龄呈强正相关。我们还发现，补充维生素C后，6种多氯联苯（多氯联苯-74、多氯联苯-118、多氯联苯-138、多氯联苯-153、多氯联苯-180和多氯联苯-187）和2种有机氯农药（4,4'-滴滴伊和4,4'-滴滴涕）的水平有统计学意义的下降，但多溴二苯醚没有。在对两性进行的更大规模研究中确认这一初步发现之前，维生素C干预可能对通过降低POPs的身体负担来保护健康具有重要的公共卫生意义。
