Clinical Research Centre, University Medical Centre Ljubljana, Zaloška Cesta 2, 1000, Ljubljana, Slovenia.
J Health Popul Nutr. 2024 Sep 3;43(1):138. doi: 10.1186/s41043-024-00627-y.
Exposure to endocrine disrupting chemicals (EDCs) can result in alterations of natural hormones in the body. The aim of this review article is to highlight the knowledge about EDCs and obesity.
A scoping review of the electronic literature was performed using PubMed platform for studies on EDCs and obesity published between the years 2013-2023. A total of 10 systematic reviews and meta-analysis studies met our inclusion criteria on more prominent EDCs focusing mainly on bisphenols, including parabens, triclosan, and phthalates, and their association with obesity.
Scoping review.
EDCs, mostly bisphenols and phthalates, are related to health effects, while there is less information on the impact of parabens and triclosan. A series of negative physiological effects involving obesogenic, diabetogenic, carcinogenic, and inflammatory mechanisms as well as epigenetic and microbiota modulations was related to a prolonged EDCs exposure. A more profound research of particular pollutants is required to illuminate the accelerating effects of particular EDCs, mixtures or their metabolites on the mechanism of the development of obesity.
Considering the characteristics of EDCs and the heterogeneity of studies, it is necessary to design specific studies of effect tracking and, in particular, education about daily preventive exposure to EDCs for the preservation of long-term public health.
接触内分泌干扰化学物质（EDCs）可能导致体内天然激素的改变。本文旨在强调关于 EDCs 与肥胖的知识。
我们使用 PubMed 平台对 2013 年至 2023 年发表的关于 EDCs 和肥胖的研究进行了电子文献的范围性回顾。共有 10 项系统评价和荟萃分析研究符合我们的纳入标准，这些研究主要关注双酚类、包括对羟基苯甲酸酯、三氯生和邻苯二甲酸酯，及其与肥胖的关系。
范围性回顾。
EDCs 主要是双酚类和邻苯二甲酸酯，与健康影响有关，而关于对羟基苯甲酸酯和三氯生的影响信息较少。一系列涉及肥胖、糖尿病、致癌和炎症机制以及表观遗传和微生物组调节的负面生理效应与长期 EDCs 暴露有关。需要对特定污染物进行更深入的研究，以阐明特定 EDCs、混合物或其代谢物对肥胖发展机制的加速作用。
考虑到 EDCs 的特征和研究的异质性，有必要设计特定的效应跟踪研究，特别是关于日常预防 EDCs 暴露的教育，以维护长期公共健康。
