ICAM - 1基因的rs5498多态性影响2型糖尿病患者颈动脉粥样硬化的进展。
Polymorphism rs5498 of the ICAM-1 gene affects the progression of carotid atherosclerosis in patients with type 2 diabetes mellitus.
作者信息
Popović Dražen, Starčević Jovana Nikolajević, Letonja Marija Šantl, Makuc Jana, Vujkovac Andreja Cokan, Pleskovič Ruda Zorc, Gaspar Ludovit, Kruzliak Peter, Petrovič Danijel
机构信息
General Hospital Rakičan, Murska Sobota, Slovenia.
Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
出版信息
Lipids Health Dis. 2016 Apr 18;15:79. doi: 10.1186/s12944-016-0247-y.
BACKGROUND
Adhesion molecules are involved in the development of atherosclerosis. An increased level of the ICAM 1 molecule is associated with numerous inflammatory diseases including atherosclerosis of carotid arteries. The rs5498 (K469E) polymorphism of the ICAM-1 gene leads to an increase in the level of serum ICAM. We investigated the association between the rs5498 (K469E) polymorphism of the ICAM-1 gene and the progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus (T2DM).
METHODS
The study included 595 patients with T2DM and 200 subjects in the control group without T2DM. The control examination was made 3.8 years after the initial examination. Indicators of atherosclerosis (carotid intima-media thickness (CIMT), total plaque sum and sum of the plaques thickness) were detected by ultrasound examination. Genetic analyses of the polymorphism rs5498 of the ICAM-1 gene were made by RT-PCR.
RESULTS
The distribution of genotypes and frequencies of rs5498 polymorphism was not significantly different between the group with type 2 diabetes ( T2DM) and the control group. Genotype EE K469E polymorphism is associated with a statistically significant annual plaques growth.
CONCLUSION
The EE genotype of the rs5498 of the ICAM-1 gene was associated with a more rapid progression of carotid atherosclerosis in patients with T2DM in comparison with other genotypes.
背景
黏附分子参与动脉粥样硬化的发展。细胞间黏附分子1（ICAM 1）分子水平升高与包括颈动脉粥样硬化在内的多种炎症性疾病相关。ICAM - 1基因的rs5498（K469E）多态性导致血清ICAM水平升高。我们研究了ICAM - 1基因的rs5498（K469E）多态性与2型糖尿病（T2DM）患者颈动脉粥样硬化进展之间的关联。
方法
该研究纳入了595例T2DM患者和200例无T2DM的对照组受试者。在初次检查3.8年后进行对照检查。通过超声检查检测动脉粥样硬化指标（颈动脉内膜中层厚度（CIMT）、总斑块面积和斑块厚度总和）。通过逆转录聚合酶链反应（RT-PCR）对ICAM - 1基因的rs5498多态性进行基因分析。
结果
2型糖尿病（T2DM）组与对照组之间rs5498多态性的基因型分布和频率无显著差异。EE K469E基因型多态性与斑块的年生长率具有统计学意义的相关性。
结论
与其他基因型相比，ICAM - 1基因rs5498的EE基因型与T2DM患者颈动脉粥样硬化的进展更快相关。
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