Milutinović A, Petrovic D
Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Slovenia.
Folia Biol (Praha). 2006;52(3):79-80.
Type 2 diabetes is one of the major risk factors for the development of CAD and subsequent MI. Inflammation, whereby ICAM-1 plays an important role, has been implicated in the pathogenesis of MI. The K469E polymorphism of the ICAM-1 gene has recently been associated with ischemic stroke, atherosclerosis of femoral arteries and microvascular complications of type 2 diabetes. We examined the association between the K469E polymorphism of the ICAM-1 gene and MI among the patients with type 2 diabetes in Slovenian population. Genotyping of the K469E polymorphism of the ICAM-1 gene was performed for 367 subjects with type 2 diabetes: 152 patients with MI and 215 with no history of CAD. The K469E ICAM-1 genotype distribution in patients with MI (EE = 21.7 %, EK = 47.4 %, KK = 30.9 %) did not differ from genotype distribution in patients without CAD (EE = 19.1 %, EK = 50.7 %, KK = 30.2 %), and the EE genotype was not associated with MI in subjects with type 2 diabetes (P = 0.5). In conclusion, the K469E polymorphism of the ICAM-1 gene was not associated with MI in patients with type 2 diabetes, and therefore may not be used as a genetic marker for MI in patients with type 2 diabetes.
2型糖尿病是发生冠心病及后续心肌梗死的主要危险因素之一。炎症在心肌梗死的发病机制中起重要作用，细胞间黏附分子-1（ICAM-1）在炎症过程中发挥重要作用。ICAM-1基因的K469E多态性最近被发现与缺血性中风、股动脉粥样硬化以及2型糖尿病的微血管并发症有关。我们在斯洛文尼亚人群的2型糖尿病患者中研究了ICAM-1基因的K469E多态性与心肌梗死之间的关联。对367例2型糖尿病患者进行了ICAM-1基因K469E多态性的基因分型：152例心肌梗死患者和215例无冠心病病史的患者。心肌梗死患者中K469E ICAM-1基因型分布（EE = 21.7%，EK = 47.4%，KK = 30.9%）与无冠心病患者的基因型分布（EE = 19.1%，EK = 50.7%，KK = 30.2%）无差异，并且在2型糖尿病患者中，EE基因型与心肌梗死无关（P = 0.5）。总之，ICAM-1基因的K469E多态性与2型糖尿病患者的心肌梗死无关，因此可能不能用作2型糖尿病患者心肌梗死的遗传标志物。
