Hoffman Julien I E
Department of Pediatrics, University of California, 925 Tiburon Boulevard, Tiburon, San Francisco, CA, 94920, USA.
Pediatr Cardiol. 2016 Jun;37(5):812-7. doi: 10.1007/s00246-016-1371-1. Epub 2016 Apr 18.
Now that pulse oximetry is used widely to screen for critical congenital heart disease, it is time to consider whether this screening method is applicable to those who live at high altitudes. Consideration of basic physical principles and reports from the literature indicate that not only is the 95 % cutoff point for arterial oxygen saturation incorrect at high altitudes, but the lower saturations are accompanied by greater variability and therefore there is the possibility of a greater percentage of false-positive screening tests at high altitudes. Because of ethnic differences in response to high altitudes, normative data will have to be collected separately in different countries and perhaps for different ethnic groups.
既然脉搏血氧测定法已被广泛用于筛查严重先天性心脏病，那么现在是时候考虑这种筛查方法是否适用于生活在高海拔地区的人群了。对基本物理原理的思考以及文献报道表明，在高海拔地区，不仅动脉血氧饱和度95%的临界值是错误的，而且较低的饱和度伴随着更大的变异性，因此在高海拔地区进行筛查测试时出现假阳性的可能性更高。由于不同种族对高海拔的反应存在差异，必须在不同国家，或许还需针对不同种族分别收集标准数据。
