Wang Bo, Zhang Jia, Wu Ya-Zhen, Lu Zhi-Hui, Wang Na, Yu Zhang-Bin
Department of Pediatrics, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, China.
Department of Neonatology, Qinghai University Affiliated Hospital, Xining, China.
Front Pediatr. 2021 Nov 1;9:771750. doi: 10.3389/fped.2021.771750. eCollection 2021.
The reference interval for pulse oxygen saturation (SpO) in neonates born at high altitudes has not been defined to date. The purpose of this study was to systematically review published studies and determine the reference interval of SpO in neonates at different altitudes. Databases of PubMed, Embase, Cochrane Library, Clinicaltrials.Gov, Chinese National Knowledge Infrastructure Database, Wanfang Database, Chinese Science Technology Journals Database, and Chinese Clinical Trial Registry were searched for studies reporting SpO in healthy neonates at different altitudes. Retrieval time was from inception of the database to August 16, 2021. The Agency for Healthcare Research and Quality checklist was used to evaluate the quality of studies. Python v3.8 was used to analyze the data. This systematic review was drafted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Seven cross-sectional studies, published between 1991 and 2020, were identified. They were from US, Mexico, Israel, Ecuador, and China. Three studies were rated as high quality and four as moderate quality. The mean SpO (with standard deviation or standard error) of neonates born in 40 different altitudes (ranging from 25 meters to 3,100 meters) were obtained. The prediction equation for calculation of the lower limit of the reference interval was established, and the reference intervals for SpO at different altitudes were determined. In healthy neonates, the lower limit of the reference interval of SpO decreases with increase in altitude. High-quality prospective studies are need to confirm our findings.
迄今为止，高海拔地区出生新生儿的脉搏血氧饱和度（SpO）参考区间尚未明确。本研究的目的是系统回顾已发表的研究，并确定不同海拔地区新生儿SpO的参考区间。检索了PubMed、Embase、Cochrane图书馆、Clinicaltrials.Gov、中国国家知识基础设施数据库、万方数据库、中国科技期刊数据库和中国临床试验注册中心等数据库，以查找报告不同海拔健康新生儿SpO的研究。检索时间为各数据库建库至2021年8月16日。采用医疗保健研究与质量机构清单评估研究质量。使用Python v3.8分析数据。本系统评价按照系统评价和Meta分析的首选报告项目（PRISMA）声明的指南起草。共纳入1991年至2020年发表的7项横断面研究。这些研究来自美国、墨西哥、以色列、厄瓜多尔和中国。3项研究被评为高质量，4项为中等质量。获得了出生于40个不同海拔（25米至3100米）的新生儿的平均SpO（及其标准差或标准误）。建立了计算参考区间下限的预测方程，并确定了不同海拔SpO的参考区间。在健康新生儿中，SpO参考区间下限随海拔升高而降低。需要高质量的前瞻性研究来证实我们的发现。
