Saye Z, Forget P P
Department of Pediatrics, University of Liège, Belgium.
J Pediatr Gastroenterol Nutr. 1989 Apr;8(3):327-32. doi: 10.1097/00005176-198904000-00011.
Clinical evaluation and prolonged esophageal pH monitoring were performed before and during treatment with cisapride (0.3 mg/kg t.i.d.) for 1 month in 19 children with reflux-associated bronchopulmonary disease. Results (mean +/- SEM) show that cisapride significantly decreases the frequency of long duration (greater than 5 min) reflux episodes (from 9.7 +/- 0.7 to 5.7 +/- 1.2), the percentage of total time pH was less than 4 (from 15.9 +/- 2.5 to 7.7 +/- 1.1%), the percentage of time pH was less than 4 at night (from 18.0 +/- 3.9 to 4.9 +/- 1.5%), the duration of the longest reflux episodes (from 44.5 +/- 6.4 to 19.7 +/- 2.7 min), as well as the duration of reflux at night (from 100.1 +/- 28.0 to 28.2 +/- 10.1 min). The frequency of reflux episodes, however, remains unaffected by cisapride. Cough fits at night disappeared completely in 12 out of 13 children. We conclude that cisapride given for 1 month significantly decreased gastroesophageal reflux as well as cough episodes at night.
对19例反流相关性支气管肺疾病患儿在使用西沙必利（0.3mg/kg，每日3次）治疗前及治疗1个月期间进行了临床评估和长时间食管pH监测。结果（均值±标准误）显示，西沙必利显著降低了长时间（大于5分钟）反流发作的频率（从9.7±0.7降至5.7±1.2）、pH值小于4的总时间百分比（从15.9±2.5降至7.7±1.1%）、夜间pH值小于4的时间百分比（从18.0±3.9降至4.9±1.5%）、最长反流发作的持续时间（从44.5±6.4降至19.7±2.7分钟）以及夜间反流的持续时间（从100.1±28.0降至28.2±10.1分钟）。然而，反流发作的频率未受西沙必利影响。13名儿童中有12名夜间咳嗽发作完全消失。我们得出结论，给予西沙必利1个月可显著减少胃食管反流以及夜间咳嗽发作。
