西沙必利和西咪替丁对胃食管反流病患者24小时食管内pH监测的影响。
Effect of cisapride and cimetidine on 24-hour intraesophageal pH monitoring in patients with gastroesophageal reflux disease.
作者信息
Chojnacki J, Tkaczewski W, Wichan P, Grzegorczyk K, Klupińska G
机构信息
Department of Gastroenterology of III Clinic of Internal Medicine MMA, Lódź, Poland.
出版信息
Mater Med Pol. 1992 Jul-Sep;24(3):196-8.
In 16 patients with symptomatic gastroesophageal reflux disease (GERD) 24-h intraesophageal pH monitoring (Medilog 1010, Oxford) was carried out after placebo, cisapride (4 x 5 mg) and cimetidine (3 x 200 mg plus 400 mg at bedtime). The per cent time at which intraesophageal pH < 4.0 (refluxive time) was analysed. Cisapride shortened daytime and postprandial refluxive time from 16.1 +/- 14.5% and 12.6 +/- 9.2% to 5.1 +/- 4.4% and 7.5 +/- 6.5%, respectively (p < 0.01, p < 0.05). Whereas, cimetidine shortened particularly night refluxive time from 24.7 +/- 14.1% to 8.8 +/- 6.9% (p < 0.01) and total time from 20.4 +/- 12.8% to 12.0 +/- 6.4% (p < 0.05).
对16例有症状的胃食管反流病（GERD）患者，在给予安慰剂、西沙必利（4×5毫克）和西咪替丁（3×200毫克，睡前加服400毫克）后，进行了24小时食管内pH监测（使用Medilog 1010，牛津）。分析了食管内pH＜4.0的时间百分比（反流时间）。西沙必利使白天和餐后反流时间分别从16.1±14.5%和12.6±9.2%缩短至5.1±4.4%和7.5±6.5%（p＜0.01，p＜0.05）。而西咪替丁特别使夜间反流时间从24.7±14.1%缩短至8.8±6.9%（p＜0.01），总时间从20.4±12.8%缩短至12.0±6.4%（p＜0.05）。
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