胃食管反流与支气管哮喘：现状与未来方向
Gastro-oesophageal reflux and bronchial asthma: current status and future directions.
作者信息
Mathew J L, Singh M, Mittal S K
机构信息
Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Postgrad Med J. 2004 Dec;80(950):701-5. doi: 10.1136/pgmj.2004.019265.
In recent years there have been several reports suggesting an association between bronchial asthma and gastro-oesophageal reflux; however a cause and effect relationship has not been proven yet. Confirmation of such a relationship is likely to have far reaching implications on the management of asthma. Reliable assessment of this issue is hampered by the presence of various lacunae in most of the published studies. Hence it is essential to carefully examine the strength of data suggesting a link between asthma and reflux. This article critically analyses currently available literature on the subject (including published reviews, meta-analyses, and randomised clinical trials in the English language) and summarises valid conclusions that can be drawn; it also proposes a framework for future studies to resolve the issue.
近年来，有几份报告表明支气管哮喘与胃食管反流之间存在关联；然而，因果关系尚未得到证实。这种关系的确认可能会对哮喘的管理产生深远影响。大多数已发表的研究存在各种缺陷，这妨碍了对该问题的可靠评估。因此，仔细审视表明哮喘与反流之间存在联系的数据的力度至关重要。本文批判性地分析了关于该主题的现有文献（包括已发表的综述、荟萃分析和英文随机临床试验），总结了可以得出的有效结论；还提出了一个未来研究框架以解决该问题。
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