Yoshihara Hikari A I, Can Emine, Karlsson Magnus, Lerche Mathilde H, Schwitter Juerg, Comment Arnaud
Institute of Physics of Biological Systems, Swiss Federal Institute of Technology, Lausanne, Switzerland.
Phys Chem Chem Phys. 2016 May 14;18(18):12409-13. doi: 10.1039/c6cp00589f. Epub 2016 Apr 19.
[1-(13)C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-(13)C]pyruvic acid, unextrapolated solution-state (13)C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.
[1-(13)C]丙酮酸是使用最广泛的超极化代谢磁共振成像剂。使用定制的在1.0 K下运行的7.0 T极化器和掺杂三苯甲基自由基的[1-(13)C]丙酮酸，在溶解并快速转移到光谱仪磁体后，测量到未外推的溶液态(13)C极化大于60%，这证明了使用优化硬件可实现的信号增强。在这些条件下较慢的极化速率在很大程度上可以通过更高的自由基浓度来克服。
