Tornelli Mauricio José, Prado Renata Martins Silva, Tornelli Helena Regina, Prado Gustavo Faibischew, Viera Patricia Verónica Aulestia, Rocha Rodney Garcia, Borsatti Maria Aparecida
Am J Dent. 2016 Feb;29(1):10-4.
To evaluate the effects of combined administration of mepivacaine with epinephrine and the diffusion agent hyaluronidase on hemodynamic and electrocardiographic parameters in healthy individuals undergoing dental surgery.
In a double-blind, split-mouth, randomized clinical trial, the cardiovascular effects induced by 2.7 mL of 2% mepivacaine with 1:100,000 epinephrine injected concomitantly with 1 mL of 75 TRU/mL hyaluronidase or placebo for inferior alveolar nerve block was evaluated in systemically healthy subjects that underwent bilateral third molar extraction in two separate sessions. Systolic and diastolic blood pressure and heart rate were monitored using oscillometric and photoplethysmographic methods in 10 clinical stages, while electrocardiographic records of 12 leads were obtained in four stages.
Hyaluronidase injected concomitantly with local anesthetic did not induce changes in blood pressure and heart rate compared to placebo. There were no instances of ST segment depression or elevation, or wide or narrow QRS complex extrasystoles in ECG. The use of mepivacaine injected concomitantly with 75 TRU/mL hyaluronidase was safe, from a cardiovascular standpoint.
评估在接受牙科手术的健康个体中，甲哌卡因与肾上腺素联合使用以及扩散剂透明质酸酶对血流动力学和心电图参数的影响。
在一项双盲、双侧、随机临床试验中，对全身健康的受试者在两个不同阶段进行双侧第三磨牙拔除时，评估了在进行下牙槽神经阻滞时，2.7毫升2%甲哌卡因与1:100,000肾上腺素同时注射1毫升75 TRU/毫升透明质酸酶或安慰剂所诱导的心血管效应。在10个临床阶段使用示波法和光电容积描记法监测收缩压、舒张压和心率，同时在4个阶段获取12导联的心电图记录。
与安慰剂相比，与局部麻醉剂同时注射透明质酸酶未引起血压和心率变化。心电图中未出现ST段压低或抬高，或宽或窄的QRS波群期前收缩。从心血管角度来看，同时注射75 TRU/毫升透明质酸酶的甲哌卡因的使用是安全的。
