Tempestini Horliana Anna Carolina Ratto, de Brito Mayara Aguilar Dias, Perez Flávio Eduardo Guillin, Simonetti Maria Prazeres Barbalho, Rocha Rodney Garcia, Borsatti Maria Aparecida
Integrated Dental Clinic, Department of Estomatology, College of Dentistry, University of São Paulo, São Paulo, Brazil.
J Oral Maxillofac Surg. 2008 Feb;66(2):286-90. doi: 10.1016/j.joms.2007.06.628.
To evaluate the duration of the effect of mepivacaine when hyaluronidase is injected immediately prior to the end of pulpal anesthesia.
Forty bilateral, symmetrical third molar surgeries were performed in 20 healthy patients. Inferior alveolar nerve block was induced using 2.8 mL 2% mepivacaine with epinephrine. Hyaluronidase (75 turbidity-reducing units) or a placebo was injected 40 minutes after the beginning of pulpar anesthesia (randomized and double-blind trial). The duration of effect in the pulpal and gingival tissues was evaluated by response to painful electrical stimuli applied to the adjacent premolar, and by mechanical stimuli (pin prick) to the vestibular gingiva, respectively.
In both tissues, the duration of anesthetic effect with hyaluronidase was longer (P < .01) than with the placebo.
Hyaluronidase increases the duration of mepivacaine in inferior alveolar nerve blocks.
评估在牙髓麻醉即将结束时立即注射透明质酸酶后甲哌卡因的作用持续时间。
对20名健康患者进行了40例双侧对称的第三磨牙手术。使用2.8 mL含肾上腺素的2%甲哌卡因进行下牙槽神经阻滞。在牙髓麻醉开始40分钟后注射透明质酸酶（75个降浊单位）或安慰剂（随机双盲试验）。分别通过对相邻前磨牙施加疼痛电刺激的反应以及对前庭牙龈的机械刺激（针刺）来评估牙髓和牙龈组织中的作用持续时间。
在两种组织中，透明质酸酶组的麻醉作用持续时间比安慰剂组更长（P <.01）。
透明质酸酶可延长下牙槽神经阻滞中甲哌卡因的作用持续时间。
