Narlı Özdemir Zehra, Şahin Uğur, Merter Mustafa, Gündüz Mehmet, Ateşağaoğlu Berna, Beksaç Meral
Ankara University Faculty of Medicine, Department of Hematology, Ankara, Turkey, Phone : +90 312 595 70 99.
Turk J Haematol. 2016 Sep 5;33(3):251-3. doi: 10.4274/tjh.2015.0433. Epub 2016 Apr 18.
Superwarfarin poisoning is usually due to chronic occult small-dose exposures and can easily be misdiagnosed and may lead to serious complications. The diagnosis can be confirmed by a concordant history and analyses of blood and urine specimens with the liquid chromatography with tandem mass spectrometry (LC-MS/MS) technique. Several months of continuous treatment with high doses of daily oral vitamin K, as well as other supportive measures, are warranted, especially when repeated laboratory measurements to help predict the treatment period are not available. In this paper, a case of superwarfarin poisoning due to chronic repetitive occupational dermal exposure to commercial rodenticides is presented.
超级华法林中毒通常是由于长期隐匿性小剂量接触所致，很容易被误诊，且可能导致严重并发症。通过一致的病史以及采用液相色谱串联质谱（LC-MS/MS）技术对血液和尿液标本进行分析可确诊。有必要进行数月的每日口服高剂量维生素K持续治疗以及其他支持措施，尤其是在无法通过重复实验室检测来帮助预测治疗周期的情况下。本文介绍了一例因长期重复性职业性皮肤接触商用灭鼠剂导致超级华法林中毒的病例。
