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一种用于鉴定血液中抗凝血灭鼠剂的 HPLC-HR-MS-MS 方法。

An HPLC-HR-MS-MS method for identification of anticoagulant rodenticides in blood.

机构信息

Federal Bureau of Investigation Laboratory, Quantico, Virginia, USA.

出版信息

J Anal Toxicol. 2013 Jul-Aug;37(6):321-5. doi: 10.1093/jat/bkt036. Epub 2013 May 10.

DOI:10.1093/jat/bkt036
PMID:23667199
Abstract

This paper presents a fully validated method for the qualitative identification of bromadiolone, brodifacoum, coumachlor, coumatetralyl, difenacoum and warfarin in whole blood specimens. Samples are protein precipitated with acetonitrile, processed via solid-phase extraction and analyzed by high-performance liquid chromatography with high resolution tandem mass spectrometric detection. Limits of detection were 10 ng/mL or better for all analytes.

摘要

本文提出了一种完全验证的方法，用于定性鉴定全血标本中的溴敌隆、溴鼠灵、杀鼠酮、氯鼠酮、敌鼠和华法林。样品用乙腈沉淀蛋白，经固相萃取处理，用高效液相色谱-高分辨率串联质谱检测分析。所有分析物的检测限均为 10ng/mL 或更好。

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