Makey Colleen M, McClean Michael D, Braverman Lewis E, Pearce Elizabeth N, Sjödin Andreas, Weinberg Janice, Webster Thomas F
Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA.
Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA.
Reprod Toxicol. 2016 Jul;62:46-52. doi: 10.1016/j.reprotox.2016.04.009. Epub 2016 Apr 14.
Polybrominated diphenyl ethers (PBDEs) are flame retardant chemicals that are persistent organic pollutants. Animal experiments and some human studies indicate that PBDEs may adversely affect male reproductive function.
To assess the association between PBDE exposure and reproductive hormones (RHs) in a North American male adult cohort.
From 2010-11, we collected three serum samples from 27 healthy adult men. We assessed associations between PBDEs and RHs using mixed effect regression models.
PBDEs were inversely associated with inhibin-B. In older men, increased concentrations of BDE-47 and BDE-100 were significantly associated with a decrease in inhibin-B, and an increase in follicular stimulating hormone (FSH).
These findings suggest PBDE exposure may affect RHs in older men. We did not measure other parameters of male reproductive function and therefore these results are preliminary.
多溴二苯醚（PBDEs）是作为持久性有机污染物的阻燃化学品。动物实验和一些人体研究表明，PBDEs可能对男性生殖功能产生不利影响。
评估北美成年男性队列中PBDE暴露与生殖激素（RHs）之间的关联。
在2010 - 2011年期间，我们从27名健康成年男性中收集了三份血清样本。我们使用混合效应回归模型评估PBDEs与RHs之间的关联。
PBDEs与抑制素B呈负相关。在老年男性中，BDE - 47和BDE - 100浓度的增加与抑制素B的降低以及促卵泡生成素（FSH）的增加显著相关。
这些发现表明PBDE暴露可能影响老年男性的生殖激素。我们没有测量男性生殖功能的其他参数，因此这些结果是初步的。
