Department of Chemistry, University of California, Berkeley, Berkeley, CA, 94720, USA.
School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang, 222005, P.R. China.
Angew Chem Int Ed Engl. 2016 May 10;55(20):6079-83. doi: 10.1002/anie.201601550. Epub 2016 Apr 20.
The gold-catalyzed enantioselective hydroazidation and hydroamination reactions of allenes are presented herein. ADC gold(I) catalysts derived from BINAM were critical for achieving high levels of enantioselectivity in both transformations. The sense of enantioinduction is reversed for the two different nucleophiles, allowing access to both enantiomers of the corresponding allylic amines using the same catalyst enantiomer.
本文介绍了金催化的丙二烯的对映选择性加氢叠氮和加氢氨反应。来源于联萘酚的 ADC 金（I）催化剂对于这两种转化都实现高对映选择性是至关重要的。对于两种不同的亲核试剂，对映诱导的感觉是相反的，因此使用相同的催化剂对映体可以获得相应的烯丙基胺的两种对映异构体。
