Sampath Karuna, Ephrussi Anne
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AJ, UK
Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, Heidelberg 69117, Germany
Development. 2016 Apr 15;143(8):1234-41. doi: 10.1242/dev.133298.
RNAs are known to regulate diverse biological processes, either as protein-encoding molecules or as non-coding RNAs. However, a third class that comprises RNAs endowed with both protein coding and non-coding functions has recently emerged. Such bi-functional 'coding and non-coding RNAs' (cncRNAs) have been shown to play important roles in distinct developmental processes in plants and animals. Here, we discuss key examples of cncRNAs and review their roles, regulation and mechanisms of action during development.
众所周知，RNA可作为蛋白质编码分子或非编码RNA来调节多种生物过程。然而，最近出现了第三类兼具蛋白质编码和非编码功能的RNA。这种双功能的“编码和非编码RNA”（cncRNA）已被证明在植物和动物的不同发育过程中发挥重要作用。在这里，我们讨论cncRNA的关键例子，并综述它们在发育过程中的作用、调控及其作用机制。
